Regulon

Regulon: R-2769

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
17-0.064742610Pr-113Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
56928 ENSG00000005206 SPPL2B Q8TCT7
11188 ENSG00000010322 NISCH Q9Y2I1
4335 ENSG00000070444 MNT Q99583
55663 ENSG00000083838 ZNF446 Q9NWS9
26205 ENSG00000101216 GMEB2 Q9UKD1
9683 ENSG00000102921 N4BP1 O75113
29997 ENSG00000105373 GLTSCR2 Q9NZM5
83637 ENSG00000122515 ZMIZ2 Q8NF64
58513 ENSG00000127527 EPS15L1 Q9UBC2
57470 ENSG00000130764 LRRC47 Q8N1G4
23005 ENSG00000137802 MAPKBP1 O60336
7786 ENSG00000139625 MAP3K12 Q12852
10498 ENSG00000142453 CARM1 Q86X55
5195 ENSG00000142655 PEX14 O75381
84939 ENSG00000160953 MUM1 K7ES53
2580 ENSG00000178950 GAK O14976
23768 ENSG00000185070 FLRT2 O43155

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
CEP-1347MAP3K13Small moleculeINHIBITORMitogen-activated protein kinase kinase kinase 9 inhibitor30
MOXONIDINENISCHSmall moleculeAGONISTNischarin agonist40
RILMENIDINENISCHSmall moleculeAGONISTNischarin agonist30

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2769

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs