Regulon

Regulon: R-2530

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
81.8570610Pr-155Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
11284 ENSG00000039650 PNKP Q96T60
5566 ENSG00000072062 PRKACA P17612
6385 ENSG00000124145 SDC4 P31431
9322 ENSG00000125733 TRIP10 W4VSQ9
3949 ENSG00000130164 LDLR P01130
2064 ENSG00000141736 ERBB2 P04626
8568 ENSG00000160214 RRP1 P56182
22904 ENSG00000278788 SBNO2 Q9Y2G9

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
POZIOTINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor inhibitor20
MM-111ERBB2UnknownINHIBITORErbB-2/ErbB-3 heterodimer inhibitor20
TRASTUZUMAB DERUXTECANTOP1AntibodyINHIBITORDNA topoisomerase I inhibitor40
VARLITINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor20
CUDC-101HDAC1Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
LAPATINIB DITOSYLATEEGFRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor40
TUCATINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
HEMAY-022ERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
MP-412ERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
TRASTUZUMAB EMTANSINEERBB2AntibodyINHIBITORTubulin inhibitor40
ZENOCUTUZUMABERBB2AntibodyINHIBITORErbB-2/ErbB-3 heterodimer inhibitor20
CANERTINIB DIHYDROCHLORIDEERBB4Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor30
NERATINIB MALEATEERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-4 inhibitor40
MUBRITINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
LAPATINIBEGFRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor40
SAPITINIBEGFRSmall moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor20
NERATINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor42
BMS-690514KDRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor20
AC-480ERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
DACOMITINIBEGFRSmall moleculeINHIBITORReceptor protein-tyrosine kinase erbB-4 inhibitor42
KBP5209ERBB2UnknownINHIBITOREpidermal growth factor receptor inhibitor10
TARLOXOTINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor inhibitor20
VANDETANIBEPHA2Small moleculeINHIBITORTyrosine-protein kinase SRC inhibitor42
ALLITINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor20
ERTUMAXOMABERBB2AntibodyCROSS-LINKING AGENTT-cell surface glycoprotein CD3 epsilon chain cross-linking agent20
TRASTUZUMAB DUOCARMAZINEERBB2AntibodyBINDING AGENTReceptor protein-tyrosine kinase erbB-2 binding agent30
MARGETUXIMABERBB2AntibodyINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
TRASTUZUMABERBB2AntibodyINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
T-DM1ERBB2AntibodyBINDING AGENTReceptor protein-tyrosine kinase erbB-2 binding agent30
CANERTINIBERBB4Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor30
BDTX189EGFRSmall moleculeNEGATIVE ALLOSTERIC MODULATOREpidermal growth factor receptor erbB1 negative allosteric modulator10
JNJ-26483327ERBB2Small moleculeINHIBITORTyrosine-protein kinase FYN inhibitor10
TESEVATINIBERBB2Small moleculeINHIBITOREphrin type-B receptor 4 inhibitor32
AFATINIB DIMALEATEEGFRSmall moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
CP-724714ERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor20
AFATINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor41
AEE-788KDRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor21
PYROTINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor30
TAK-285EGFRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor10
PERTUZUMABERBB2AntibodyINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
GSK-690693PRKACBSmall moleculeINHIBITORProtein kinase C (PKC) inhibitor10
GANCOTAMABTOP2AAntibodyINHIBITORDNA topoisomerase II alpha inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2530

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs