Regulon

Regulon: R-2488

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
71.0094510Pr-97Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
4358 ENSG00000115204 MPV17 P39210
9784 ENSG00000115234 SNX17 Q15036
55686 ENSG00000118242 MREG Q8N565
83464 ENSG00000138613 APH1B Q8WW43
9246 ENSG00000156587 UBE2L6 O14933
54741 ENSG00000213625 LEPROT O15243
5500 ENSG00000213639 PPP1CB P62140

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
BEGACESTATAPH1ASmall moleculeINHIBITORGamma-secretase inhibitor10
TARENFLURBILAPH1ASmall moleculeMODULATORGamma-secretase modulator30
SEMAGACESTATAPH1ASmall moleculeINHIBITORGamma-secretase inhibitor30
AVAGACESTATAPH1ASmall moleculeINHIBITORGamma-secretase inhibitor20
RG-4733APH1ASmall moleculeINHIBITORGamma-secretase inhibitor21

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2488

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs