Regulon

Regulon: R-2162

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
220.83117710Pr-133Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
3077 ENSG00000010704 HFE Q30201
27430 ENSG00000038274 MAT2B Q9NZL9
841 ENSG00000064012 CASP8 Q14790
3993 ENSG00000073350 LLGL2 Q6P1M3
6788 ENSG00000104375 STK3 Q13188
6019 ENSG00000107014 RLN2 P04090
51174 ENSG00000108423 TUBD1 Q9UJT1
64149 ENSG00000108666 C17orf75 Q9HAS0
2348 ENSG00000110195 FOLR1 P15328
4179 ENSG00000117335 CD46 P15529
466 ENSG00000123268 ATF1 P18846
9111 ENSG00000123609 NMI Q13287
23408 ENSG00000124523 SIRT5 Q9NXA8
5562 ENSG00000132356 PRKAA1 Q13131
10390 ENSG00000134255 CEPT1 Q9Y6K0
10010 ENSG00000136560 TANK Q92844
29761 ENSG00000155313 USP25 Q9UHP3
55669 ENSG00000171109 MFN1 Q8IWA4
55106 ENSG00000172123 SLFN12 Q8IYM2
5074 ENSG00000177425 PAWR Q96IZ0
57402 ENSG00000189334 S100A14 Q9HCY8
23607 ENSG00000198087 CD2AP Q9Y5K6

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
NIVOCASANCASP1Small moleculeINHIBITORCaspase-9 inhibitor20
MIRVETUXIMAB SORAVTANSINEFOLR1AntibodyINHIBITORTubulin inhibitor30
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20
VINTAFOLIDEFOLR1Small moleculeBINDING AGENTFolate receptor alpha binding agent30
FARLETUZUMABFOLR1AntibodyINHIBITORFolate receptor alpha inhibitor30

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2162

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs