Regulon

Regulon: R-1954

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
7-1.12910Pr-123Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
2322 ENSG00000122025 FLT3 P36888
84612 ENSG00000124171 PARD6B Q9BYG5
8471 ENSG00000133124 IRS4 O14654
1295 ENSG00000144810 COL8A1 P27658
223117 ENSG00000153993 SEMA3D O95025
81285 ENSG00000167332 OR51E2 Q9H255
4892 ENSG00000197893 NRAP Q86VF7

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
MIDOSTAURINKITSmall moleculeINHIBITORVascular endothelial growth factor receptor 2 inhibitor40
CRENOLANIBPDGFRBSmall moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor32
PACRITINIBFLT3Small moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor30
SUNITINIBPDGFRBSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor42
AKN-028FLT3Small moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor20
AMUVATINIBFLT3Small moleculeINHIBITORPlatelet-derived growth factor receptor alpha inhibitor20
SORAFENIB TOSYLATEPDGFRBSmall moleculeINHIBITORStem cell growth factor receptor inhibitor42
SORAFENIBFLT3Small moleculeINHIBITORStem cell growth factor receptor inhibitor42
PEXIDARTINIB HYDROCHLORIDECSF1RSmall moleculeINHIBITORMacrophage colony stimulating factor receptor inhibitor40
FF-10101FLT3Small moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor10
TANDUTINIBFLT3Small moleculeINHIBITORPlatelet-derived growth factor receptor beta inhibitor22
CDX-301FLT3ProteinAGONISTTyrosine-protein kinase receptor FLT3 agonist20
FORETINIBTEKSmall moleculeINHIBITORTyrosine-protein kinase TIE-2 inhibitor20
LESTAURTINIBJAK2Small moleculeINHIBITORTyrosine-protein kinase JAK2 inhibitor30
SUNITINIB MALATEPDGFRBSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor42
XL-999PDGFRBSmall moleculeINHIBITORFibroblast growth factor receptor inhibitor20
DOVITINIBPDGFRBSmall moleculeINHIBITORVascular endothelial growth factor receptor inhibitor31
SU-014813PDGFRBSmall moleculeINHIBITORVascular endothelial growth factor receptor inhibitor20
ENMD-2076FLT3Small moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor20
AMG553FLT3CellBINDING AGENTTyrosine-protein kinase receptor FLT3 binding agent10
FEDRATINIB HYDROCHLORIDEJAK2Small moleculeINHIBITORTyrosine-protein kinase JAK2 inhibitor40
FLYSYNFLT3AntibodyINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor10
ZOTIRACICLIBCDK9Small moleculeINHIBITORCyclin-dependent kinase 9 inhibitor11
GILTERITINIB FUMARATEAXLSmall moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor40
IMC-EB10FLT3AntibodyINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor10
PEXIDARTINIBFLT3Small moleculeINHIBITORMacrophage colony stimulating factor receptor inhibitor42
RG-1530KDRSmall moleculeINHIBITORVascular endothelial growth factor receptor inhibitor10
QUIZARTINIBPDGFRBSmall moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor30
KW-2449AURKBSmall moleculeINHIBITORTyrosine-protein kinase ABL inhibitor10
GILTERITINIBAXLSmall moleculeINHIBITORTyrosine-protein kinase receptor UFO inhibitor40
LINIFANIBCSF1RSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor30
4SC-203KDRSmall moleculeINHIBITORTyrosine-protein kinase receptor FLT3 inhibitor10
SKLB1028ABL1Small moleculeINHIBITORTyrosine-protein kinase ABL inhibitor30
AT-9283AURKBSmall moleculeINHIBITORTyrosine-protein kinase JAK3 inhibitor20
CM-082FLT3Small moleculeINHIBITORVascular endothelial growth factor receptor 2 inhibitor30
FAMITINIBKDRSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor30
FEDRATINIBJAK2Small moleculeINHIBITORTyrosine-protein kinase JAK2 inhibitor40
ENMD-981693PDGFRBSmall moleculeINHIBITORPlatelet-derived growth factor receptor inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1954

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs