Regulon

Regulon: R-1759

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
7-1.7191210Pr-62Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
2932 ENSG00000082701 GSK3B P49841
23046 ENSG00000116852 KIF21B O75037
11113 ENSG00000122966 CIT O14578
80319 ENSG00000168772 CXXC4 J9JIF5
7267 ENSG00000182670 TTC3 P53804
51466 ENSG00000196405 EVL Q9UI08
9223 ENSG00000282956 MAGI1 H7C4U7

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
TIDEGLUSIBGSK3BSmall moleculeINHIBITORGlycogen synthase kinase-3 beta inhibitor20
LY-2090314GSK3BSmall moleculeINHIBITORGlycogen synthase kinase-3 alpha inhibitor20
9-ING-41GSK3BSmall moleculeINHIBITORGlycogen synthase kinase-3 beta inhibitor21
LITHIUM CARBONATEIMPA1Small moleculeINHIBITORGlycogen synthase kinase-3 inhibitor40
LITHIUM CITRATEIMPA1Small moleculeINHIBITORGlycogen synthase kinase-3 inhibitor40

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1759

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs