Regulon – gbmMINER Portal

Regulon: R-1722

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
9	0.322997	1	0	Pr-173

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5010	ENSG00000013297	CLDN11	O75508
8614	ENSG00000113739	STC2	O76061
2632	ENSG00000114480	GBE1	Q04446
390	ENSG00000115963	RND3	P61587
2048	ENSG00000133216	EPHB2	Q6NVW1
2977	ENSG00000152402	GUCY1A2	P33402
3481	ENSG00000167244	IGF2	P01344
9019	ENSG00000197965	MPZL1	O95297
10381	ENSG00000258947	TUBB3	G3V2N6

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ERIBULIN MESYLATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SAGOPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	2
AGS-16C3F	TUBB1	Unknown	DISRUPTING AGENT	Tubulin disrupting agent	2	0
CINACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
DOCETAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SODIUM NITROPRUSSIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
OLINCIGUAT	GUCY1B1	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Soluble guanylate cyclase positive allosteric modulator	2	0
FOSBRETABULIN DISODIUM	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
XENTUZUMAB	IGF2	Antibody	INHIBITOR	Insulin-like growth factor I inhibitor	2	0
VINCRISTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
VINFLUNINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LEXIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	1
VINCRISTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ENFORTUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Nectin-4 binding agent	4	0
VINORELBINE TARTRATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LIFASTUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Sodium-dependent phosphate transport protein 2B binding agent	2	0
KOS-1584	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
PRALUZATAMAB RAVTANSINE	ALCAM	Antibody	INHIBITOR	Tubulin inhibitor	2	0
LADIRATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
PACLITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
CROLIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
PENTAERYTHRITOL TETRANITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
PACLITAXEL POLIGLUMEX	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
VERICIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
PATUPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	1
ASG-5ME	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
ANG1005	LRP1	Protein	BINDING AGENT	Prolow-density lipoprotein receptor-related protein 1 binding agent	3	2
PINATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VERUBULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	2
VINBLASTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VINORELBINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
RIOCIGUAT	GUCY1B1	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Soluble guanylate cyclase positive allosteric modulator	4	0
NITROGLYCERIN	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
VANDETANIB	EPHA2	Small molecule	INHIBITOR	Tyrosine-protein kinase SRC inhibitor	4	2
DAVUNETIDE	TUBB1	Protein	STABILISER	Tubulin stabiliser	2	0
BELANTAMAB MAFODOTIN	TUBB1	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	4	0
FOSBRETABULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	3	0
ABT-751	TUBB1	Small molecule	INHIBITOR	Tubulin beta inhibitor	2	0
NITRIC OXIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
MIRVETUXIMAB SORAVTANSINE	FOLR1	Antibody	INHIBITOR	Tubulin inhibitor	3	0
IXABEPILONE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
POLATUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	B-cell antigen receptor complex-associated protein beta chain binding agent	4	0
T-900607	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
ATACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
APRUTUMAB IXADOTIN	TUBB1	Antibody	BINDING AGENT	Fibroblast growth factor receptor 2 binding agent	1	0
PLINABULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	3	0
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4	0
DOLASTATIN-10	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
FOSBRETABULIN TROMETHAMINE	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
NITROPRUSSIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
SAR-408701	TUBB1	Unknown	BINDING AGENT	Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent	3	0
CABAZITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
DUSIGITUMAB	IGF2	Antibody	INHIBITOR	Insulin-like growth factor II inhibitor	2	0
PACLITAXEL DOCOSAHEXAENOIC ACID	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
ERIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BMS-275183	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
ISOSORBIDE MONONITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
INDUSATUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Heat-stable enterotoxin receptor binding agent	2	0
GLEMBATUMUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Transmembrane glycoprotein NMB binding agent	2	0
COLCHICINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
RUNCACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
VANDORTUZUMAB VEDOTIN	STEAP1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VINBLASTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BRENTUXIMAB VEDOTIN	TNFRSF8	Antibody	INHIBITOR	Tubulin inhibitor	4	0
EPOTHILONE D	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
SOFITUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Mucin-16 binding agent	1	0
INDIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
PRALICIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
ISOSORBIDE DINITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
AZINTUXIZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
LAROTAXEL	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
RG-7841	TUBB1	Unknown	INHIBITOR	Tubulin inhibitor	1	0
LORVOTUZUMAB MERTANSINE	NCAM1	Antibody	INHIBITOR	Tubulin inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1722

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs