Regulon – gbmMINER Portal

Regulon: R-1705

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
40	-0.814703	1	0	Pr-62

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
8913	ENSG00000006283	CACNA1G	O43497
51412	ENSG00000077080	ACTL6B	O94805
4216	ENSG00000085511	MAP3K4	Q9Y6R4
11069	ENSG00000091428	RAPGEF4	Q8WZA2
57084	ENSG00000091664	SLC17A6	Q9P2U8
9985	ENSG00000100918	REC8	O95072
11075	ENSG00000104435	STMN2	Q93045
27075	ENSG00000106537	TSPAN13	O95857
26271	ENSG00000112029	FBXO5	Q9UKT4
2888	ENSG00000115290	GRB14	Q14449
10983	ENSG00000118816	CCNI	Q14094
3229	ENSG00000123364	HOXC13	P31276
3227	ENSG00000123388	HOXC11	O43248
23677	ENSG00000130147	SH3BP4	Q9P0V3
3110	ENSG00000130675	MNX1	P50219
26586	ENSG00000136108	CKAP2	Q8WWK9
25822	ENSG00000137094	DNAJB5	O75953
7020	ENSG00000137203	TFAP2A	A0A6E1XE14
81796	ENSG00000137571	SLCO5A1	Q9H2Y9
2674	ENSG00000151892	GFRA1	A0A804HJK2
55521	ENSG00000152503	TRIM36	Q9NQ86
3815	ENSG00000157404	KIT	P10721
54861	ENSG00000163788	SNRK	Q9NRH2
63876	ENSG00000165495	PKNOX2	Q96KN3
190	ENSG00000169297	NR0B1	P51843
91752	ENSG00000170396	ZNF804A	Q7Z570
8507	ENSG00000171617	ENC1	Q53XS2
167227	ENSG00000172795	DCP2	Q8IU60
3642	ENSG00000173404	INSM1	Q01101
80059	ENSG00000176204	LRRTM4	Q86VH4
4603	ENSG00000185697	MYBL1	P10243
9687	ENSG00000196208	GREB1	Q4ZG55
51427	ENSG00000196247	ZNF107	A0A024R5Y9
10793	ENSG00000198039	ZNF273	Q14593
9745	ENSG00000198597	ZNF536	O15090
55219	ENSG00000204178	TMEM57	Q8N5G2
5520	ENSG00000221914	PPP2R2A	P63151
3206	ENSG00000253293	HOXA10	P31260
54551	ENSG00000254585	MAGEL2	Q9UJ55
4082	ENSG00000277443	MARCKS	P29966

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ACT-709478	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	2	0
TERODILINE	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
PAZOPANIB	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	1
MIDOSTAURIN	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	0
OSI-930	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	1	0
TIVOZANIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	2
ETHOSUXIMIDE	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	0
SUNITINIB	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
AMUVATINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	2	0
SORAFENIB TOSYLATE	PDGFRB	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
TELATINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
SORAFENIB	FLT3	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
PEXIDARTINIB HYDROCHLORIDE	CSF1R	Small molecule	INHIBITOR	Macrophage colony stimulating factor receptor inhibitor	4	0
SUVECALTAMIDE	CACNA1G	Small molecule	MODULATOR	Voltage-gated T-type calcium channel modulator	2	0
PAZOPANIB HYDROCHLORIDE	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	0
VATALANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	1
PHENSUXIMIDE	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	0
PARAMETHADIONE	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	0
TANDUTINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	2
LIATERMIN	GFRA1	Protein	AGONIST	GDNF family receptor alpha-1 agonist	1	0
FORETINIB	TEK	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
IMATINIB MESYLATE	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
SUNITINIB MALATE	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
XL-999	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	2	0
DOVITINIB	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	1
SU-014813	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
ENMD-2076	FLT3	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	2	0
ANLOTINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 3 inhibitor	3	2
METHSUXIMIDE	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	0
IMATINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
GABAPENTIN ENACARBIL	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
TRIMETHADIONE	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	0
PREGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
XL-820	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0
ATAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	2	0
GABAPENTIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
MASITINIB	KIT	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	3	0
SEMAXANIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
MOTESANIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor RET inhibitor	3	0
BEPRIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
PEXIDARTINIB	FLT3	Small molecule	INHIBITOR	Macrophage colony stimulating factor receptor inhibitor	4	2
SULOCTIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
QUIZARTINIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	0
IMAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	3	0
AVAPRITINIB	PDGFRA	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	4	0
AMG-191	KIT	Antibody	INHIBITOR	Stem cell growth factor receptor inhibitor	1	0
CM-082	FLT3	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	0
CEDIRANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	3
REGORAFENIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	4	2
MIBEFRADIL	CACNA1G	Small molecule	BLOCKER	Voltage-gated T-type calcium channel blocker	4	1
FAMITINIB	KDR	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
RIPRETINIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	4	0
TIVOZANIB HYDROCHLORIDE	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1705

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs