Regulon – gbmMINER Portal

Regulon: R-1673

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
18	0.338654	1	0	Pr-121

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
4345	ENSG00000091972	CD200	F8W7G1
57415	ENSG00000114405	C3orf14	Q9HBI5
3227	ENSG00000123388	HOXC11	O43248
64919	ENSG00000127152	BCL11B	L8B567
79805	ENSG00000143494	VASH2	Q86V25
3815	ENSG00000157404	KIT	P10721
80178	ENSG00000162062	C16orf59	H3BND0
92595	ENSG00000169951	ZNF764	Q96H86
8507	ENSG00000171617	ENC1	Q53XS2
167227	ENSG00000172795	DCP2	Q8IU60
3642	ENSG00000173404	INSM1	Q01101
9687	ENSG00000196208	GREB1	Q4ZG55
80055	ENSG00000197121	PGAP1	Q75T13
3201	ENSG00000197576	HOXA4	Q00056
3223	ENSG00000197757	HOXC6	P09630
151230	ENSG00000213160	KLHL23	Q8NBE8
3206	ENSG00000253293	HOXA10	P31260
23619	ENSG00000269699	ZIM2	Q9NZV7

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
PAZOPANIB	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	1
MIDOSTAURIN	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	4	0
OSI-930	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	1	0
TIVOZANIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	2
SUNITINIB	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
AMUVATINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	2	0
SORAFENIB TOSYLATE	PDGFRB	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
TELATINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	2	0
SORAFENIB	FLT3	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	4	2
PEXIDARTINIB HYDROCHLORIDE	CSF1R	Small molecule	INHIBITOR	Macrophage colony stimulating factor receptor inhibitor	4	0
PAZOPANIB HYDROCHLORIDE	LCK	Small molecule	INHIBITOR	Fibroblast growth factor receptor 1 inhibitor	4	0
VATALANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	1
TANDUTINIB	FLT3	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	2	2
FORETINIB	TEK	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	2	0
IMATINIB MESYLATE	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
SUNITINIB MALATE	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	4	2
XL-999	PDGFRB	Small molecule	INHIBITOR	Fibroblast growth factor receptor inhibitor	2	0
DOVITINIB	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	1
SAMALIZUMAB	CD200	Antibody	INHIBITOR	OX-2 membrane glycoprotein inhibitor	2	0
SU-014813	PDGFRB	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	2	0
ENMD-2076	FLT3	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	2	0
ANLOTINIB	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 3 inhibitor	3	2
IMATINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	3
XL-820	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0
MASITINIB	KIT	Small molecule	INHIBITOR	Stem cell growth factor receptor inhibitor	3	0
SEMAXANIB	KDR	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	3	0
MOTESANIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor RET inhibitor	3	0
PEXIDARTINIB	FLT3	Small molecule	INHIBITOR	Macrophage colony stimulating factor receptor inhibitor	4	2
QUIZARTINIB	PDGFRB	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	0
AVAPRITINIB	PDGFRA	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	4	0
AMG-191	KIT	Antibody	INHIBITOR	Stem cell growth factor receptor inhibitor	1	0
CM-082	FLT3	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor 2 inhibitor	3	0
CEDIRANIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	3
REGORAFENIB	KDR	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	4	2
FAMITINIB	KDR	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	3	0
RIPRETINIB	KIT	Small molecule	INHIBITOR	Platelet-derived growth factor receptor alpha inhibitor	4	0
TIVOZANIB HYDROCHLORIDE	KIT	Small molecule	INHIBITOR	Vascular endothelial growth factor receptor inhibitor	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1673

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs