Regulon – gbmMINER Portal

Regulon: R-1618

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
6	1.71576	1	0	Pr-124

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
2191	ENSG00000078098	FAP	Q12884
958	ENSG00000101017	CD40	P25942
8564	ENSG00000117009	KMO	O15229
26191	ENSG00000134242	PTPN22	E9PMT0
915	ENSG00000167286	CD3D	P04234
6352	ENSG00000274233	CCL5	D0EI67

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase
SELICRELUMAB	CD40	Antibody	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	1
GLOFITAMAB	CD3D	Antibody	BINDING AGENT	T cell surface glycoprotein CD3 binding agent	3
LUCATUMUMAB	CD40	Antibody	ANTAGONIST	Tumor necrosis factor receptor superfamily member 5 antagonist	2
BLINATUMOMAB	CD3D	Antibody	CROSS-LINKING AGENT	T cell surface glycoprotein CD3 cross-linking agent	4
TECLISTAMAB	CD3D	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	2
FLOTETUZUMAB	CD3D	Antibody	BINDING AGENT	T cell surface glycoprotein CD3 binding agent	2
CDX-1140	CD40	Unknown	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
F19 131I	FAP	Antibody	BINDING AGENT	Fibroblast activation protein alpha binding agent	3
MOSUNETUZUMAB	CD3D	Antibody	BINDING AGENT	B-lymphocyte antigen CD20 binding agent	3
DACETUZUMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
ELRANATAMAB	CD3D	Antibody	BINDING AGENT	T cell surface glycoprotein CD3 binding agent	2
PG-102	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
BLESELUMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2
SIMLUKAFUSP ALFA	FAP	Protein	BINDING AGENT	Fibroblast activation protein alpha binding agent	2
TALQUETAMAB	CD3D	Antibody	BINDING AGENT	G-protein coupled receptor family C group 5 member D binding agent	2
CD40 LIGAND	CD40	Unknown	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
SOTIGALIMAB	CD40	Antibody	AGONIST	Tumor necrosis factor receptor superfamily member 5 agonist	2
CATUMAXOMAB	CD3D	Antibody	CROSS-LINKING AGENT	Epithelial cell adhesion molecule cross-linking agent	4
MUROMONAB-CD3	CD3D	Antibody	INHIBITOR	T cell surface glycoprotein CD3 inhibitor	4
ODRONEXTAMAB	CD3D	Antibody	BINDING AGENT	T cell surface glycoprotein CD3 binding agent	2
FORALUMAB	CD3D	Antibody	INHIBITOR	T cell surface glycoprotein CD3 inhibitor	2
SIBROTUZUMAB	FAP	Antibody	BINDING AGENT	Fibroblast activation protein alpha binding agent	1
EPCORITAMAB	CD3D	Antibody	BINDING AGENT	B-lymphocyte antigen CD20 binding agent	3
ISCALIMAB	CD40	Antibody	INHIBITOR	Tumor necrosis factor receptor superfamily member 5 inhibitor	2

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1618

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs