Regulon

Regulon: R-1387

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
10	2.27344	1	7	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5141	ENSG00000065989	PDE4A	P27815
51172	ENSG00000103174	NAGPA	Q9UK23
23646	ENSG00000105223	PLD3	A0A024R0Q4
25789	ENSG00000105696	TMEM59L	Q9UK28
7277	ENSG00000127824	TUBA4A	P68366
146691	ENSG00000175662	TOM1L2	Q6ZVM7
79751	ENSG00000177542	SLC25A22	Q9H936
27132	ENSG00000178773	CPNE7	Q9UBL6
5575	ENSG00000188191	PRKAR1B	P31321
55753	ENSG00000197444	OGDHL	Q9ULD0

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ERIBULIN MESYLATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SAGOPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	2
AGS-16C3F	TUBB1	Unknown	DISRUPTING AGENT	Tubulin disrupting agent	2	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
DOCETAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
FOSBRETABULIN DISODIUM	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
CHF-6001	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
VINCRISTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
VINFLUNINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LEXIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	1
VINCRISTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ENFORTUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Nectin-4 binding agent	4	0
VINORELBINE TARTRATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LIFASTUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Sodium-dependent phosphate transport protein 2B binding agent	2	0
KOS-1584	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
APREMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
PRALUZATAMAB RAVTANSINE	ALCAM	Antibody	INHIBITOR	Tubulin inhibitor	2	0
DYPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	4	0
OGLEMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LADIRATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
FLAVOXATE HYDROCHLORIDE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
PACLITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
CROLIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
MK-0873	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
TOFIMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
PACLITAXEL POLIGLUMEX	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
PATUPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	1
PENTOXIFYLLINE	PDE4A	Small molecule	ANTAGONIST	Adenosine A2 receptor antagonist	4	0
ASG-5ME	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
ANG1005	LRP1	Protein	BINDING AGENT	Prolow-density lipoprotein receptor-related protein 1 binding agent	3	2
DROTAVERINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
PINATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
DIPYRIDAMOLE	SLC29A1	Small molecule	INHIBITOR	3',5'-cyclic phosphodiesterase inhibitor	4	0
VERUBULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	2
VINBLASTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VINORELBINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
DAVUNETIDE	TUBB1	Protein	STABILISER	Tubulin stabiliser	2	0
BELANTAMAB MAFODOTIN	TUBB1	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	4	0
FOSBRETABULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	3	0
IBUDILAST	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	3	1
MIRVETUXIMAB SORAVTANSINE	FOLR1	Antibody	INHIBITOR	Tubulin inhibitor	3	0
GSK-256066	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
ROFLUMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
IXABEPILONE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
POLATUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	B-cell antigen receptor complex-associated protein beta chain binding agent	4	0
T-900607	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
DIFAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
APRUTUMAB IXADOTIN	TUBB1	Antibody	BINDING AGENT	Fibroblast growth factor receptor 2 binding agent	1	0
PLINABULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	3	0
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4	0
DOLASTATIN-10	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
FOSBRETABULIN TROMETHAMINE	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
CILOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
SAR-408701	TUBB1	Unknown	BINDING AGENT	Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent	3	0
CABAZITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
FLAVOXATE	PDE8B	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
PACLITAXEL DOCOSAHEXAENOIC ACID	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
ERIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BMS-275183	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
INDUSATUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Heat-stable enterotoxin receptor binding agent	2	0
CRISABOROLE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
GLEMBATUMUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Transmembrane glycoprotein NMB binding agent	2	0
COLCHICINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VANDORTUZUMAB VEDOTIN	STEAP1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VINBLASTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BRENTUXIMAB VEDOTIN	TNFRSF8	Antibody	INHIBITOR	Tubulin inhibitor	4	0
TETOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
AMLEXANOX	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
EPOTHILONE D	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
SOFITUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Mucin-16 binding agent	1	0
INDIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
OXTRIPHYLLINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
AZINTUXIZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
HT-0712	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LOTAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LAROTAXEL	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
RG-7841	TUBB1	Unknown	INHIBITOR	Tubulin inhibitor	1	0
CC-11050	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LORVOTUZUMAB MERTANSINE	NCAM1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
THEOPHYLLINE	ADORA1	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
AMINOPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1387

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-02046	TCHH	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-12463	PTDSS1	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-14319	STK31	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-17669	DPY19L2P1	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-24228	WBSCR17	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-27228	HTR3A	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE
CMF-30393	CLCN7	down-regulates	SREBF2	activates	R-1387	5	1	Drugs (82) Regulator Drugs (0) Regulon Drugs (82) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TELISOTUZUMAB VEDOTIN, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, CABAZITAXEL, FLAVOXATE, PACLITAXEL DOCOSAHEXAENOIC ACID, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, CRISABOROLE, GLEMBATUMUMAB VEDOTIN, COLCHICINE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BRENTUXIMAB VEDOTIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, OXTRIPHYLLINE, AZINTUXIZUMAB VEDOTIN, HT-0712, LOTAMILAST, LAROTAXEL, RG-7841, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, AMINOPHYLLINE

Regulon: R-1387

Regulon Summary

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Causal Flows

Causal Mechanistic Flows for Regulon R-1387

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Regulon Drugs (82)

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Regulon Drugs (82)