Regulon

Regulon: R-1370

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
39	2.51112	1	12	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5646	ENSG00000010438	PRSS3	A0A7P0MNE9
23154	ENSG00000020129	NCDN	Q9UBB6
5141	ENSG00000065989	PDE4A	P27815
782	ENSG00000067191	CACNB1	Q02641
65985	ENSG00000081760	AACS	Q86V21
23368	ENSG00000088808	PPP1R13B	Q96KQ4
7301	ENSG00000092445	TYRO3	Q06418
51172	ENSG00000103174	NAGPA	Q9UK23
25789	ENSG00000105696	TMEM59L	Q9UK28
6804	ENSG00000106089	STX1A	Q16623
10612	ENSG00000110171	TRIM3	O75382
10120	ENSG00000115073	ACTR1B	P42025
57576	ENSG00000117245	KIF17	Q9P2E2
2185	ENSG00000120899	PTK2B	Q14289
9572	ENSG00000126368	NR1D1	F1D8S3
2002	ENSG00000126767	ELK1	P19419
7277	ENSG00000127824	TUBA4A	P68366
6861	ENSG00000129990	SYT5	A0A024R4N8
4294	ENSG00000130758	MAP3K10	Q02779
3706	ENSG00000137825	ITPKA	P23677
79180	ENSG00000142634	EFHD2	A0A024QZ77
8525	ENSG00000149091	DGKZ	Q13574
57731	ENSG00000160460	SPTBN4	Q9H254
55295	ENSG00000167487	KLHL26	Q53HC5
3761	ENSG00000168135	KCNJ4	P48050
7480	ENSG00000169884	WNT10B	O00744
8941	ENSG00000171450	CDK5R2	Q13319
64837	ENSG00000174996	KLC2	Q9H0B6
1212	ENSG00000175416	CLTB	P09497
146691	ENSG00000175662	TOM1L2	Q6ZVM7
10458	ENSG00000175866	BAIAP2	Q9UQB8
2902	ENSG00000176884	GRIN1	Q05586
8541	ENSG00000177380	PPFIA3	O75145
79751	ENSG00000177542	SLC25A22	Q9H936
5575	ENSG00000188191	PRKAR1B	P31321
55753	ENSG00000197444	OGDHL	Q9ULD0
50861	ENSG00000197457	STMN3	A0A0J9YXY4
955	ENSG00000197586	ENTPD6	O75354
727800	ENSG00000212864	RNF208	Q9H0X6

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ERIBULIN MESYLATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SAGOPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	2
AGS-16C3F	TUBB1	Unknown	DISRUPTING AGENT	Tubulin disrupting agent	2	0
TERODILINE	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
ACAMPROSATE CALCIUM	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
DOCETAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
FOSBRETABULIN DISODIUM	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
CHF-6001	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
VINCRISTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
VINFLUNINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
AV-101	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	2	0
LEXIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	1
VINCRISTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ENFORTUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Nectin-4 binding agent	4	0
MEMANTINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	2
VINORELBINE TARTRATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LIFASTUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Sodium-dependent phosphate transport protein 2B binding agent	2	0
KOS-1584	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
APREMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
PRALUZATAMAB RAVTANSINE	ALCAM	Antibody	INHIBITOR	Tubulin inhibitor	2	0
DYPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	4	0
OGLEMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LADIRATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
MEMANTINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
FLAVOXATE HYDROCHLORIDE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
PACLITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
ORPHENADRINE HYDROCHLORIDE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
CROLIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
MK-0873	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
TOFIMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
PACLITAXEL POLIGLUMEX	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
PATUPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	1
PENTOXIFYLLINE	PDE4A	Small molecule	ANTAGONIST	Adenosine A2 receptor antagonist	4	0
ASG-5ME	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
ANG1005	LRP1	Protein	BINDING AGENT	Prolow-density lipoprotein receptor-related protein 1 binding agent	3	2
DROTAVERINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
CEP-1347	MAP3K13	Small molecule	INHIBITOR	Mitogen-activated protein kinase kinase kinase 9 inhibitor	3	0
PINATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
DIPYRIDAMOLE	SLC29A1	Small molecule	INHIBITOR	3',5'-cyclic phosphodiesterase inhibitor	4	0
VERUBULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	2
VINBLASTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VINORELBINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
DEFACTINIB	PTK2B	Small molecule	INHIBITOR	Focal adhesion kinase 1 inhibitor	2	0
DAVUNETIDE	TUBB1	Protein	STABILISER	Tubulin stabiliser	2	0
BELANTAMAB MAFODOTIN	TUBB1	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	4	0
FOSBRETABULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	3	0
TRAXOPRODIL	GRIN1	Small molecule	ANTAGONIST	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist	2	0
NERAMEXANE	GRIN1	Small molecule	ANTAGONIST	Neuronal acetylcholine receptor; alpha9/alpha10 antagonist	3	0
EVT-101	GRIN1	Small molecule	ANTAGONIST	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist	2	0
KETAMINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
IBUDILAST	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	3	1
MIRVETUXIMAB SORAVTANSINE	FOLR1	Antibody	INHIBITOR	Tubulin inhibitor	3	0
GSK-256066	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
ROFLUMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
IXABEPILONE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
POLATUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	B-cell antigen receptor complex-associated protein beta chain binding agent	4	0
ORPHENADRINE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
T-900607	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
DIFAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
APRUTUMAB IXADOTIN	TUBB1	Antibody	BINDING AGENT	Fibroblast growth factor receptor 2 binding agent	1	0
PLINABULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	3	0
GABAPENTIN ENACARBIL	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4	0
DOLASTATIN-10	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
FOSBRETABULIN TROMETHAMINE	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
CILOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
SAR-408701	TUBB1	Unknown	BINDING AGENT	Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent	3	0
FELBAMATE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
CABAZITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
FLAVOXATE	PDE8B	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
AMANTADINE HYDROCHLORIDE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
PACLITAXEL DOCOSAHEXAENOIC ACID	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
PREGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
RAPASTINEL	GRIN1	Protein	PARTIAL AGONIST	Glutamate [NMDA] receptor partial agonist	3	0
ATAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	2	0
GABAPENTIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
ERIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BMS-275183	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
INDUSATUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Heat-stable enterotoxin receptor binding agent	2	0
LANICEMINE	GRIN1	Small molecule	BLOCKER	Glutamate [NMDA] receptor blocker	2	0
CRISABOROLE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
RISLENEMDAZ	GRIN1	Small molecule	ANTAGONIST	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist	2	0
GLEMBATUMUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Transmembrane glycoprotein NMB binding agent	2	0
COLCHICINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
ACAMPROSATE	GABRG2	Small molecule	POSITIVE MODULATOR	GABA-A receptor; anion channel positive modulator	4	0
RALFINAMIDE	MAOB	Small molecule	INHIBITOR	Monoamine oxidase B inhibitor	3	0
VANDORTUZUMAB VEDOTIN	STEAP1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VINBLASTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BEPRIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
BRENTUXIMAB VEDOTIN	TNFRSF8	Antibody	INHIBITOR	Tubulin inhibitor	4	0
SULOCTIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
GW468816	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	2	0
NERAMEXANE MESYLATE	GRIN1	Small molecule	ANTAGONIST	Neuronal acetylcholine receptor; alpha9/alpha10 antagonist	3	0
IMAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	3	0
TETOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
AMLEXANOX	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
EPOTHILONE D	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
SOFITUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Mucin-16 binding agent	1	0
INDIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
ORPHENADRINE CITRATE	SCN2A	Small molecule	BLOCKER	Sodium channel alpha subunit blocker	4	0
OXTRIPHYLLINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
RADIPRODIL	GRIN1	Small molecule	ANTAGONIST	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist	2	0
AZINTUXIZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
APIMOSTINEL	GRIN1	Protein	PARTIAL AGONIST	Glutamate [NMDA] receptor partial agonist	2	0
HT-0712	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
ESKETAMINE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
INDANTADOL	GRIN1	Small molecule	INHIBITOR	Monoamine oxidase A inhibitor	2	0
LOTAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
ESKETAMINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
LAROTAXEL	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
RG-7841	TUBB1	Unknown	INHIBITOR	Tubulin inhibitor	1	0
AMANTADINE	GRIN1	Small molecule	ANTAGONIST	Glutamate [NMDA] receptor antagonist	4	0
CC-11050	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LORVOTUZUMAB MERTANSINE	NCAM1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
THEOPHYLLINE	ADORA1	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
KETAMINE HYDROCHLORIDE	GRIN1	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Glutamate [NMDA] receptor negative allosteric modulator	4	0
AMINOPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
CONTELTINIB	PTK2	Small molecule	INHIBITOR	Protein tyrosine kinase 2 beta inhibitor	1	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1370

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-02951	ADCY5	down-regulates	SP1	represses	R-1370	8	5	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-03075	SFRS2IP	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-04281	RBPJL	up-regulates	SP1	represses	R-1370	8	2	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-05927	CACNA1E	up-regulates	SP1	represses	R-1370	8	2	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-06196	MYO5B	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-10472	LPA	up-regulates	SP1	represses	R-1370	8	2	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-11478	SPEN	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-11555	PREX2	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-12431	HSPG2	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-17835	CSF2RB	up-regulates	SP1	represses	R-1370	8	5	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-23310	CD44	up-regulates	SP1	represses	R-1370	8	1	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB
CMF-25151	FLT3	up-regulates	SP1	represses	R-1370	8	2	Drugs (120) Regulator Drugs (0) Regulon Drugs (120) ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

Regulon: R-1370

Regulon Summary

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Causal Mechanistic Flows for Regulon R-1370

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