Regulon – gbmMINER Portal

Regulon: R-1369

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
41	1.53803	1	0	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
5798	ENSG00000054356	PTPRN	Q16849
2983	ENSG00000061918	GUCY1B3	Q02153
537	ENSG00000071553	ATP6AP1	Q15904
5566	ENSG00000072062	PRKACA	P17612
9891	ENSG00000074590	NUAK1	O60285
2782	ENSG00000078369	GNB1	A0A140VJJ8
23136	ENSG00000082397	EPB41L3	J3QS55
3797	ENSG00000084731	KIF3C	O14782
610	ENSG00000099822	HCN2	Q9UL51
1917	ENSG00000101210	EEF1A2	Q05639
333	ENSG00000105290	APLP1	P51693
6324	ENSG00000105711	SCN1B	Q07699
5730	ENSG00000107317	PTGDS	A0A024R8G3
81855	ENSG00000107819	SFXN3	Q9BWM7
30850	ENSG00000109089	CDR2L	Q86X02
2026	ENSG00000111674	ENO2	P09104
55700	ENSG00000116871	MAP7D1	Q3KQU3
6253	ENSG00000125744	RTN2	O75298
27345	ENSG00000135643	KCNMB4	Q86W47
23148	ENSG00000136274	NACAD	O15069
274	ENSG00000136717	BIN1	O00499
7280	ENSG00000137267	TUBB2A	Q13885
1838	ENSG00000138101	DTNB	O60941
526	ENSG00000147416	ATP6V1B2	P21281
10435	ENSG00000149798	CDC42EP2	O14613
5305	ENSG00000150867	PIP4K2A	P48426
7070	ENSG00000154096	THY1	P04216
808	ENSG00000160014	CALM3	P0DP25
1173	ENSG00000161203	AP2M1	Q96CW1
55323	ENSG00000166173	LARP6	Q9BRS8
10501	ENSG00000167680	SEMA6B	Q9H3T3
3777	ENSG00000171303	KCNK3	O14649
253982	ENSG00000174939	ASPHD1	Q5U4P2
79605	ENSG00000177614	PGBD5	Q8N414
54913	ENSG00000178718	RPP25	Q9BUL9
527	ENSG00000185883	ATP6V0C	P27449
23396	ENSG00000186111	PIP5K1C	O60331
4155	ENSG00000197971	MBP	P02686
55861	ENSG00000244274	DBNDD2	Q9BQY9
89927	ENSG00000278823	C16orf45	Q96MC5
11182	ENSG00000281165	SLC2A6	Q9UGQ3

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ERIBULIN MESYLATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SAGOPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	2
AGS-16C3F	TUBB1	Unknown	DISRUPTING AGENT	Tubulin disrupting agent	2	0
CINACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
DOCETAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SODIUM NITROPRUSSIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
OLINCIGUAT	GUCY1B1	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Soluble guanylate cyclase positive allosteric modulator	2	0
FOSBRETABULIN DISODIUM	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
VINCRISTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
VINFLUNINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LEXIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	1
VINCRISTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ENFORTUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Nectin-4 binding agent	4	0
VINORELBINE TARTRATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LIFASTUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Sodium-dependent phosphate transport protein 2B binding agent	2	0
KOS-1584	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
PRALUZATAMAB RAVTANSINE	ALCAM	Antibody	INHIBITOR	Tubulin inhibitor	2	0
LADIRATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
PACLITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
CROLIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
PENTAERYTHRITOL TETRANITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
PACLITAXEL POLIGLUMEX	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
VERICIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
PATUPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	1
ASG-5ME	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
ANG1005	LRP1	Protein	BINDING AGENT	Prolow-density lipoprotein receptor-related protein 1 binding agent	3	2
PINATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VERUBULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	2
VINBLASTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VINORELBINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
RIOCIGUAT	GUCY1B1	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Soluble guanylate cyclase positive allosteric modulator	4	0
NITROGLYCERIN	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
DESFLURANE	GABRG2	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4	0
DAVUNETIDE	TUBB1	Protein	STABILISER	Tubulin stabiliser	2	0
BELANTAMAB MAFODOTIN	TUBB1	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	4	0
FOSBRETABULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	3	0
ABT-751	TUBB1	Small molecule	INHIBITOR	Tubulin beta inhibitor	2	0
NITRIC OXIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
MIRVETUXIMAB SORAVTANSINE	FOLR1	Antibody	INHIBITOR	Tubulin inhibitor	3	0
IXABEPILONE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
POLATUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	B-cell antigen receptor complex-associated protein beta chain binding agent	4	0
T-900607	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
ATACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
PLITIDEPSIN	EEF1A2	Small molecule	INHIBITOR	Elongation factor 1-alpha 2 inhibitor	3	0
APRUTUMAB IXADOTIN	TUBB1	Antibody	BINDING AGENT	Fibroblast growth factor receptor 2 binding agent	1	0
PLINABULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	3	0
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4	0
DOLASTATIN-10	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
FOSBRETABULIN TROMETHAMINE	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
NITROPRUSSIDE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
SAR-408701	TUBB1	Unknown	BINDING AGENT	Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent	3	0
CABAZITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
PACLITAXEL DOCOSAHEXAENOIC ACID	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
ISOFLURANE	KCNK10	Small molecule	OPENER	Potassium channel subfamily K member 2 opener	4	0
ERIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BMS-275183	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
ISOSORBIDE MONONITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
INDUSATUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Heat-stable enterotoxin receptor binding agent	2	0
GLEMBATUMUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Transmembrane glycoprotein NMB binding agent	2	0
COLCHICINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
RUNCACIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
VANDORTUZUMAB VEDOTIN	STEAP1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VINBLASTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BRENTUXIMAB VEDOTIN	TNFRSF8	Antibody	INHIBITOR	Tubulin inhibitor	4	0
SEVOFLURANE	KCNK2	Small molecule	OPENER	Potassium channel subfamily K member 18 opener	4	0
EPOTHILONE D	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
SOFITUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Mucin-16 binding agent	1	0
INDIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
PRALICIGUAT	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	2	0
ISOSORBIDE DINITRATE	GUCY1B1	Small molecule	ACTIVATOR	Soluble guanylate cyclase activator	4	0
AZINTUXIZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
DOXAPRAM	KCNK3	Small molecule	BLOCKER	Potassium channel subfamily K member 9 blocker	4	0
DOXAPRAM HYDROCHLORIDE	KCNK3	Small molecule	BLOCKER	Potassium channel subfamily K member 9 blocker	4	0
LAROTAXEL	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
RG-7841	TUBB1	Unknown	INHIBITOR	Tubulin inhibitor	1	0
GSK-690693	PRKACB	Small molecule	INHIBITOR	Protein kinase C (PKC) inhibitor	1	0
LORVOTUZUMAB MERTANSINE	NCAM1	Antibody	INHIBITOR	Tubulin inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1369

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs