Regulon: R-1251
Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.
Regulon Summary
Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.
| Genes | Cox Hazard Ratio | Regulators | Causal Flows | Transcriptional Programs | Hallmarks |
|---|---|---|---|---|---|
| 11 | 1.43002 | 1 | 0 | Pr-85 |           |
Regulon Genes
List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.
| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 54884 | ENSG00000042445 | RETSAT | Q6NUM9 |
| 8714 | ENSG00000108846 | ABCC3 | O15438 |
| 84263 | ENSG00000119471 | HSDL2 | Q6YN16 |
| 3764 | ENSG00000121361 | KCNJ8 | Q15842 |
| 388 | ENSG00000143878 | RHOB | P62745 |
| 2560 | ENSG00000163288 | GABRB1 | P18505 |
| 55788 | ENSG00000168216 | LMBRD1 | Q9NUN5 |
| 8309 | ENSG00000168306 | ACOX2 | Q99424 |
| 8722 | ENSG00000174080 | CTSF | Q9UBX1 |
| 28955 | ENSG00000182108 | DEXI | O95424 |
| 5500 | ENSG00000213639 | PPP1CB | P62140 |
Regulon Drugs
| Name | Approved Symbol | Type | Action Type | Mechanism of Action | Max Trial Phase | Max GBM Phase |
|---|---|---|---|---|---|---|
| MIDAZOLAM HYDROCHLORIDE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| CHLORDIAZEPOXIDE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ALPRAZOLAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ESTAZOLAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ACAMPROSATE CALCIUM | GABRG2 | Small molecule | POSITIVE MODULATOR | GABA-A receptor; anion channel positive modulator | 4 | 0 |
| MIDAZOLAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ETIFOXINE | GABRG2 | Small molecule | ANTAGONIST | GABA-A receptor; anion channel antagonist | 3 | 0 |
| ZOPICLONE | GABRB3 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; agonist GABA site positive allosteric modulator | 4 | 0 |
| THIOPENTAL SODIUM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ESZOPICLONE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| PRAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| FLUMAZENIL | GABRG2 | Small molecule | ALLOSTERIC ANTAGONIST | GABA-A receptor; anion channel allosteric antagonist | 4 | 0 |
| RESEQUINIL | GABRG2 | Small molecule | INVERSE AGONIST | GABA-A receptor; anion channel inverse agonist | 2 | 0 |
| THIOPENTAL | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| CLONAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| PENTOBARBITAL | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| QUAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| METHARBITAL | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| PROPOFOL | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| PADSEVONIL | SV2C | Small molecule | MODULATOR | Synaptic vesicle protein modulator | 3 | 0 |
| DESFLURANE | GABRG2 | Small molecule | OPENER | Potassium channel subfamily K member 2 opener | 4 | 0 |
| ZALEPLON | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator | 4 | 0 |
| BUTALBITAL | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| DARIGABAT | GABRG2 | Small molecule | AGONIST | GABA-A receptor; anion channel agonist | 2 | 0 |
| TRIAZOLAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| GABOXADOL | GABRB3 | Small molecule | AGONIST | GABA-A receptor; agonist GABA site agonist | 3 | 0 |
| CLORAZEPATE DIPOTASSIUM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| DIAZOXIDE | KCNJ8 | Small molecule | OPENER | Potassium channel, inwardly rectifying, subfamily J, member 11 opener | 4 | 0 |
| ETOMIDATE | GABRG2 | Small molecule | POSITIVE MODULATOR | GABA-A receptor; anion channel positive modulator | 4 | 0 |
| REMIMAZOLAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| CENOBAMATE | SCN2A | Small molecule | INHIBITOR | Sodium channel alpha subunit inhibitor | 4 | 0 |
| CLOBAZAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| HSK-3486 | GABRG2 | Small molecule | AGONIST | GABA-A receptor; anion channel agonist | 3 | 0 |
| HALAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| MEPROBAMATE | GABRG2 | Small molecule | AGONIST | GABA-A receptor; anion channel agonist | 4 | 0 |
| ISOFLURANE | KCNK10 | Small molecule | OPENER | Potassium channel subfamily K member 2 opener | 4 | 0 |
| OXAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| FLURAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| CLORAZEPIC ACID | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| BREXANOLONE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| ACAMPROSATE | GABRG2 | Small molecule | POSITIVE MODULATOR | GABA-A receptor; anion channel positive modulator | 4 | 0 |
| PRIMIDONE | SCN2A | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| DIAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| TEMAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| REMIMAZOLAM BESYLATE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| SEVOFLURANE | KCNK2 | Small molecule | OPENER | Potassium channel subfamily K member 18 opener | 4 | 0 |
| CLOMETHIAZOLE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| LORAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| GANAXOLONE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 3 | 0 |
| ADIPIPLON | GABRG2 | Small molecule | PARTIAL AGONIST | GABA-A receptor; anion channel partial agonist | 2 | 0 |
| TOPIRAMATE | CA4 | Small molecule | POSITIVE MODULATOR | GABA-A receptor; anion channel positive modulator | 4 | 0 |
| ZOLPIDEM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator | 4 | 0 |
| ZOLPIDEM TARTRATE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA A receptor alpha-1/beta-1/gamma-2 positive allosteric modulator | 4 | 0 |
| FLURAZEPAM HYDROCHLORIDE | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| CLOTIAZEPAM | GABRG2 | Small molecule | POSITIVE ALLOSTERIC MODULATOR | GABA-A receptor; anion channel positive allosteric modulator | 4 | 0 |
| METHOXYFLURANE | GABRG2 | Small molecule | AGONIST | Glycine receptor (alpha-1/beta) agonist | 4 | 0 |
Causal Flows
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulon R-1251
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|