Regulon – gbmMINER Portal

Regulon: R-1173

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
13	-1.17337	1	0	Pr-159

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
55644	ENSG00000092094	OSGEP	Q9NPF4
26277	ENSG00000092330	TINF2	H0YL20
6729	ENSG00000100883	SRP54	P61011
1432	ENSG00000112062	MAPK14	B4E0K5
23767	ENSG00000125848	FLRT3	Q9NZU0
55795	ENSG00000126226	PCID2	Q5JVF3
57570	ENSG00000126814	TRMT5	G3V494
10038	ENSG00000129484	PARP2	Q9UGN5
10001	ENSG00000133997	MED6	O75586
54407	ENSG00000134294	SLC38A2	Q96QD8
23589	ENSG00000153048	CARHSP1	Q9Y2V2
9337	ENSG00000155508	CNOT8	Q9UFF9
151011	ENSG00000186522	10-Sep	Q9P0V9

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
RUCAPARIB	PARP1	Small molecule	INHIBITOR	PARP 1, 2 and 3 inhibitor	4	0
PAMIPARIB	PARP1	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase-1 inhibitor	3	1
FX-005	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
SEMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
TALMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
DILMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
OLAPARIB	PARP1	Small molecule	INHIBITOR	PARP 1, 2 and 3 inhibitor	4	2
TAK-715	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
TALAZOPARIB	PARP1	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase 2 inhibitor	4	2
NEFLAMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
ARRY-797	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	3	0
RUCAPARIB CAMSYLATE	PARP1	Small molecule	INHIBITOR	PARP 1, 2 and 3 inhibitor	4	0
VX-702	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
RALIMETINIB	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	1
BMS-582949	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
VELIPARIB	PARP1	Small molecule	INHIBITOR	PARP 1, 2 and 3 inhibitor	3	2
ACUMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
PF-03715455	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
AZD-7624	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
2X-121	TNKS2	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase-1 inhibitor	2	0
GSK-610677	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	1	0
NIRAPARIB	PARP2	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase 2 inhibitor	4	2
PEXMETINIB	MAPK14	Small molecule	INHIBITOR	Tyrosine-protein kinase TIE-2 inhibitor	1	0
LOSMAPIMOD	MAPK11	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	3	0
DORAMAPIMOD	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
NIRAPARIB TOSYLATE	PARP1	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase 2 inhibitor	4	0
TALAZOPARIB TOSYLATE	PARP1	Small molecule	INHIBITOR	Poly [ADP-ribose] polymerase 2 inhibitor	4	0
PH-797804	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
KC-706	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0
PG-760564	MAPK14	Small molecule	INHIBITOR	MAP kinase p38 alpha inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1173

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs