Regulon

Regulon: R-1079

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
91.1550810Pr-147Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
55622 ENSG00000018699 TTC27 Q6P3X3
5307 ENSG00000069011 PITX1 P78337
6185 ENSG00000118705 RPN2 P04844
8932 ENSG00000134046 MBD2 Q9UBB5
7157 ENSG00000141510 TP53 P04637
54901 ENSG00000145996 CDKAL1 Q5VV42
10018 ENSG00000153094 BCL2L11 O43521
9601 ENSG00000155660 PDIA4 A0A090N8Y2
5479 ENSG00000166794 PPIB P23284

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
IDASANUTLINTP53Small moleculeINHIBITORTumour suppressor p53/oncoprotein Mdm2 inhibitor31
AMG-232TP53Small moleculeINHIBITORTumour suppressor p53/oncoprotein Mdm2 inhibitor20
CENERSEN SODIUMTP53OligonucleotideANTISENSE INHIBITORp53 mRNA antisense inhibitor20
CONTUSUGENE LADENOVECTP53GenePOSITIVE MODULATORCellular tumor antigen p53 positive modulator20
TEPRASIRANTP53OligonucleotideRNAI INHIBITORp53 mRNA RNAi inhibitor30
APG115TP53Small moleculeINHIBITORTumour suppressor p53/oncoprotein Mdm2 inhibitor20
CENERSENTP53OligonucleotideANTISENSE INHIBITORp53 mRNA antisense inhibitor20
EPRENETAPOPTTP53Small moleculeSTABILISERCellular tumor antigen p53 stabiliser30

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1079

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs