Regulon

Regulon: R-1008

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
8-0.61385410Pr-66Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
4904 ENSG00000065978 YBX1 P67809
6624 ENSG00000075618 FSCN1 Q16658
6449 ENSG00000104969 SGTA O43765
5296 ENSG00000105647 PIK3R2 O00459
55116 ENSG00000121775 TMEM39B Q9GZU3
8535 ENSG00000141582 CBX4 O00257
28511 ENSG00000168256 NKIRAS2 Q9NYR9
6598 ENSG00000275837 SMARCB1 G5E975

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1008

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs