Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IRF9 - interferon regulatory factor 9
Function
Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10379 | ENSG00000213928 | IRF9 | Q00978 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000213928 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00305 | COL6A3 | up-regulates | IRF9 | activates | R-1457 | 15 | 3 | Drugs (2) |
| CMF-00306 | COL6A3 | up-regulates | IRF9 | activates | R-1446 | 15 | 3 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-00307 | COL6A3 | up-regulates | IRF9 | activates | R-1451 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05847 | LGI2 | up-regulates | IRF9 | activates | R-1459 | 15 | 1 | Drugs (1) |
| CMF-07669 | SAMD9L | down-regulates | IRF9 | activates | R-1457 | 15 | 1 | Drugs (2) |
| CMF-09130 | RSBN1L | up-regulates | IRF9 | activates | R-1452 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09131 | RSBN1L | up-regulates | IRF9 | activates | R-1457 | 15 | 2 | Drugs (2) |
| CMF-10477 | LRBA | up-regulates | IRF9 | activates | R-1448 | 15 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-10480 | LRBA | up-regulates | IRF9 | activates | R-1451 | 15 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15941 | KCNB2 | up-regulates | IRF9 | activates | R-1446 | 15 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-17505 | CNTNAP3 | up-regulates | IRF9 | activates | R-1457 | 15 | 1 | Drugs (2) |
| CMF-17679 | MRPL32 | down-regulates | IRF9 | activates | R-1457 | 15 | 1 | Drugs (2) |
| CMF-18145 | NWD1 | up-regulates | IRF9 | activates | R-1457 | 15 | 1 | Drugs (2) |
| CMF-18273 | MEGF8 | up-regulates | IRF9 | activates | R-1447 | 15 | 3 | Drugs (2) |
| CMF-18274 | MEGF8 | up-regulates | IRF9 | activates | R-1446 | 15 | 3 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-18275 | MEGF8 | up-regulates | IRF9 | activates | R-1451 | 15 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20085 | TDRD9 | up-regulates | IRF9 | activates | R-1447 | 15 | 8 | Drugs (2) |
| CMF-20088 | TDRD9 | up-regulates | IRF9 | activates | R-1452 | 15 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20089 | TDRD9 | up-regulates | IRF9 | activates | R-1446 | 15 | 8 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-20091 | TDRD9 | up-regulates | IRF9 | activates | R-1451 | 15 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20092 | TDRD9 | up-regulates | IRF9 | activates | R-1459 | 15 | 8 | Drugs (1) |
| CMF-21552 | ENPP7 | up-regulates | IRF9 | activates | R-1457 | 15 | 2 | Drugs (2) |
| CMF-24909 | NLRP1 | up-regulates | IRF9 | activates | R-1446 | 15 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-24911 | NLRP1 | up-regulates | IRF9 | activates | R-1451 | 15 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25010 | IQSEC3 | down-regulates | IRF9 | activates | R-1447 | 15 | 4 | Drugs (2) |
| CMF-25012 | IQSEC3 | down-regulates | IRF9 | activates | R-1457 | 15 | 4 | Drugs (2) |
| CMF-25013 | IQSEC3 | down-regulates | IRF9 | activates | R-1446 | 15 | 4 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-25746 | INPP5D | down-regulates | IRF9 | activates | R-1446 | 15 | 1 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-26550 | MLL2 | down-regulates | IRF9 | activates | R-1457 | 15 | 4 | Drugs (2) |
| CMF-26551 | MLL2 | down-regulates | IRF9 | activates | R-1446 | 15 | 4 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-28250 | ZIC1 | down-regulates | IRF9 | activates | R-1446 | 15 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-29404 | EPHA8 | up-regulates | IRF9 | activates | R-1457 | 15 | 1 | Drugs (2) |
| CMF-33701 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF9 | activates | R-1457 | 15 | 3 | Drugs (2) |