Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
FOXD3 - forkhead box D3
Function
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 27022 | ENSG00000187140 | FOXD3 | Q9UJU5 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000187140 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01315 | OR2H1 | up-regulates | FOXD3 | represses | R-575 | 25 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-02864 | SRRM2 | down-regulates | FOXD3 | represses | R-575 | 25 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-03708 | DSP | down-regulates | FOXD3 | represses | R-576 | 25 | 15 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-03711 | DSP | down-regulates | FOXD3 | represses | R-577 | 25 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04895 | ABCC5 | up-regulates | FOXD3 | represses | R-582 | 25 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-04898 | ABCC5 | up-regulates | FOXD3 | represses | R-572 | 25 | 7 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-04899 | ABCC5 | up-regulates | FOXD3 | represses | R-575 | 25 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-05009 | NUP210L | up-regulates | FOXD3 | represses | R-578 | 25 | 4 | Drugs (5) |
| CMF-05011 | NUP210L | up-regulates | FOXD3 | represses | R-572 | 25 | 4 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-05904 | BCL6 | down-regulates | FOXD3 | represses | R-572 | 25 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-06319 | MATN4 | up-regulates | FOXD3 | represses | R-578 | 25 | 3 | Drugs (5) |
| CMF-06320 | MATN4 | up-regulates | FOXD3 | represses | R-572 | 25 | 3 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-07470 | LRRIQ1 | down-regulates | FOXD3 | represses | R-575 | 25 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-08630 | SLC4A7 | down-regulates | FOXD3 | represses | R-576 | 25 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-09411 | ZIC4 | down-regulates | FOXD3 | represses | R-575 | 25 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-10812 | KIAA1012 | down-regulates | FOXD3 | represses | R-572 | 25 | 1 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-11081 | SNX9 | up-regulates | FOXD3 | represses | R-577 | 25 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13139 | SLC26A8 | down-regulates | FOXD3 | represses | R-576 | 25 | 10 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-13142 | SLC26A8 | down-regulates | FOXD3 | represses | R-575 | 25 | 10 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-13257 | SULF2 | up-regulates | FOXD3 | represses | R-578 | 25 | 4 | Drugs (5) |
| CMF-13259 | SULF2 | up-regulates | FOXD3 | represses | R-572 | 25 | 4 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-15519 | RASGRF1 | down-regulates | FOXD3 | represses | R-582 | 25 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-15520 | RASGRF1 | down-regulates | FOXD3 | represses | R-572 | 25 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-16695 | SI | down-regulates | FOXD3 | represses | R-582 | 25 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-17370 | TBC1D8 | down-regulates | FOXD3 | represses | R-576 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-18187 | CDH19 | down-regulates | FOXD3 | represses | R-575 | 25 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-19139 | PTPRR | down-regulates | FOXD3 | represses | R-576 | 25 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-19247 | NF1 | down-regulates | FOXD3 | represses | R-582 | 25 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-19249 | NF1 | down-regulates | FOXD3 | represses | R-576 | 25 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-19251 | NF1 | down-regulates | FOXD3 | represses | R-578 | 25 | 8 | Drugs (5) |
| CMF-19253 | NF1 | down-regulates | FOXD3 | represses | R-572 | 25 | 8 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-19254 | NF1 | down-regulates | FOXD3 | represses | R-575 | 25 | 8 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-20293 | FREM1 | down-regulates | FOXD3 | represses | R-576 | 25 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20938 | KLHL13 | down-regulates | FOXD3 | represses | R-576 | 25 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20940 | KLHL13 | down-regulates | FOXD3 | represses | R-578 | 25 | 6 | Drugs (5) |
| CMF-21010 | KRTAP4-7 | down-regulates | FOXD3 | represses | R-582 | 25 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-21012 | KRTAP4-7 | down-regulates | FOXD3 | represses | R-576 | 25 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-21013 | KRTAP4-7 | down-regulates | FOXD3 | represses | R-578 | 25 | 8 | Drugs (5) |
| CMF-21016 | KRTAP4-7 | down-regulates | FOXD3 | represses | R-572 | 25 | 8 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)SULTHIAME, CILENGITIDE, SENICAPOC, DKN-01, CG250 177LU, GIRENTUXIMAB, CG250 111IN, INTETUMUMAB, TOSEDOSTAT, BHQ-880, ABITUZUMAB |
| CMF-21017 | KRTAP4-7 | down-regulates | FOXD3 | represses | R-575 | 25 | 8 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-25858 | PIK3CA | down-regulates | FOXD3 | represses | R-576 | 25 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-25986 | CTNNA2 | down-regulates | FOXD3 | represses | R-576 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-26685 | FBN2 | down-regulates | FOXD3 | represses | R-576 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-26687 | FBN2 | down-regulates | FOXD3 | represses | R-575 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)IMSIDOLIMAB, OLECLUMAB, NERAMEXANE, NERAMEXANE MESYLATE, OCRIPLASMIN, SPESOLIMAB |
| CMF-29480 | SEMA3E | down-regulates | FOXD3 | represses | R-582 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-29482 | SEMA3E | down-regulates | FOXD3 | represses | R-576 | 25 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-30213 | TEP1 | down-regulates | FOXD3 | represses | R-577 | 25 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31205 | RAG1 | down-regulates | FOXD3 | represses | R-577 | 25 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |