Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
POU3F1 - POU class 3 homeobox 1
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5453 | ENSG00000185668 | POU3F1 | Q03052 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000185668 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01189 | SKAP2 | down-regulates | POU3F1 | represses | R-1660 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02267 | CHD9 | up-regulates | POU3F1 | represses | R-1663 | 25 | 1 | Drugs (2) |
| CMF-03050 | OR5D14 | down-regulates | POU3F1 | represses | R-1645 | 25 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-03322 | C14orf115 | down-regulates | POU3F1 | represses | R-1649 | 25 | 2 | Drugs (4) |
| CMF-04249 | RBPJL | down-regulates | POU3F1 | represses | R-1646 | 25 | 8 | Drugs (4) |
| CMF-04250 | RBPJL | down-regulates | POU3F1 | represses | R-1649 | 25 | 8 | Drugs (4) |
| CMF-04251 | RBPJL | down-regulates | POU3F1 | represses | R-1645 | 25 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-04254 | RBPJL | down-regulates | POU3F1 | represses | R-1660 | 25 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05504 | IL18RAP | down-regulates | POU3F1 | represses | R-1666 | 25 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05643 | ITGB7 | up-regulates | POU3F1 | represses | R-1666 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05809 | SYNE2 | up-regulates | POU3F1 | represses | R-1663 | 25 | 3 | Drugs (2) |
| CMF-05811 | SYNE2 | up-regulates | POU3F1 | represses | R-1666 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06369 | PCDHGA1 | down-regulates | POU3F1 | represses | R-1649 | 25 | 4 | Drugs (4) |
| CMF-07297 | NOD2 | down-regulates | POU3F1 | represses | R-1646 | 25 | 6 | Drugs (4) |
| CMF-07298 | NOD2 | down-regulates | POU3F1 | represses | R-1649 | 25 | 6 | Drugs (4) |
| CMF-07299 | NOD2 | down-regulates | POU3F1 | represses | R-1645 | 25 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-07301 | NOD2 | down-regulates | POU3F1 | represses | R-1651 | 25 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-07931 | SLC27A2 | down-regulates | POU3F1 | represses | R-1649 | 25 | 5 | Drugs (4) |
| CMF-08502 | HEMGN | down-regulates | POU3F1 | represses | R-1645 | 25 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-09142 | RSBN1L | down-regulates | POU3F1 | represses | R-1660 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12700 | ABCA10 | down-regulates | POU3F1 | represses | R-1660 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16442 | SUSD5 | down-regulates | POU3F1 | represses | R-1645 | 25 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-17158 | CDH18 | down-regulates | POU3F1 | represses | R-1646 | 25 | 3 | Drugs (4) |
| CMF-17160 | CDH18 | down-regulates | POU3F1 | represses | R-1660 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20425 | CUX2 | down-regulates | POU3F1 | represses | R-1649 | 25 | 5 | Drugs (4) |
| CMF-20429 | CUX2 | down-regulates | POU3F1 | represses | R-1651 | 25 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-21493 | POTEF | down-regulates | POU3F1 | represses | R-1660 | 25 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22101 | OR2T34 | up-regulates | POU3F1 | represses | R-1646 | 25 | 3 | Drugs (4) |
| CMF-24331 | SMCHD1 | down-regulates | POU3F1 | represses | R-1649 | 25 | 4 | Drugs (4) |
| CMF-26634 | C5AR1 | down-regulates | POU3F1 | represses | R-1649 | 25 | 2 | Drugs (4) |
| CMF-27460 | SDK1 | down-regulates | POU3F1 | represses | R-1649 | 25 | 6 | Drugs (4) |
| CMF-27465 | SDK1 | down-regulates | POU3F1 | represses | R-1660 | 25 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29423 | EPHA8 | down-regulates | POU3F1 | represses | R-1663 | 25 | 2 | Drugs (2) |
| CMF-29424 | EPHA8 | down-regulates | POU3F1 | represses | R-1649 | 25 | 2 | Drugs (4) |
| CMF-29500 | SEMA3E | down-regulates | POU3F1 | represses | R-1645 | 25 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-29874 | ABCC9 | down-regulates | POU3F1 | represses | R-1651 | 25 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM, VESENCUMAB |
| CMF-33428 | TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLS | down-regulates | POU3F1 | represses | R-1649 | 25 | 8 | Drugs (4) |