Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

MAF - MAF bZIP transcription factor

Function

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
4094	ENSG00000178573	MAF	O75444

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000178573 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-01170	SKAP2	up-regulates	MAF	activates	R-185	19	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-01171	SKAP2	up-regulates	MAF	activates	R-173	19	2	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-01413	SLC28A3	down-regulates	MAF	activates	R-177	19	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-01414	SLC28A3	down-regulates	MAF	activates	R-184	19	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01415	SLC28A3	down-regulates	MAF	activates	R-175	19	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-01416	SLC28A3	down-regulates	MAF	activates	R-179	19	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-03524	GRIN2A	up-regulates	MAF	activates	R-184	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03525	GRIN2A	up-regulates	MAF	activates	R-189	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03755	DSP	up-regulates	MAF	activates	R-185	19	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-03757	DSP	up-regulates	MAF	activates	R-173	19	8	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-03759	DSP	up-regulates	MAF	activates	R-176	19	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DIPYRIDAMOLE
CMF-04374	TYK2	down-regulates	MAF	activates	R-179	19	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-04405	COL12A1	up-regulates	MAF	activates	R-189	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04734	ADAMTS20	up-regulates	MAF	activates	R-185	19	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-04735	ADAMTS20	up-regulates	MAF	activates	R-189	19	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05014	NUP210L	down-regulates	MAF	activates	R-185	19	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-05016	NUP210L	down-regulates	MAF	activates	R-189	19	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05017	NUP210L	down-regulates	MAF	activates	R-183	19	5	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG
CMF-05018	NUP210L	down-regulates	MAF	activates	R-179	19	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-05905	BCL6	up-regulates	MAF	activates	R-185	19	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-06326	MATN4	down-regulates	MAF	activates	R-183	19	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG
CMF-06327	MATN4	down-regulates	MAF	activates	R-179	19	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-08257	KIF4A	down-regulates	MAF	activates	R-185	19	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-08258	KIF4A	down-regulates	MAF	activates	R-174	19	8	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-08259	KIF4A	down-regulates	MAF	activates	R-175	19	8	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-08260	KIF4A	down-regulates	MAF	activates	R-173	19	8	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-08264	KIF4A	down-regulates	MAF	activates	R-179	19	8	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-08758	FBLN2	up-regulates	MAF	activates	R-177	19	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-09178	TANC2	up-regulates	MAF	activates	R-184	19	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09179	TANC2	up-regulates	MAF	activates	R-175	19	4	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-09181	TANC2	up-regulates	MAF	activates	R-189	19	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09369	CUL1	up-regulates	MAF	activates	R-184	19	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09370	CUL1	up-regulates	MAF	activates	R-175	19	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-11405	CYP4F22	up-regulates	MAF	activates	R-174	19	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-11406	CYP4F22	up-regulates	MAF	activates	R-184	19	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11407	CYP4F22	up-regulates	MAF	activates	R-175	19	6	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-11408	CYP4F22	up-regulates	MAF	activates	R-173	19	6	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-11409	CYP4F22	up-regulates	MAF	activates	R-189	19	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11410	CYP4F22	up-regulates	MAF	activates	R-179	19	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-11543	PREX2	up-regulates	MAF	activates	R-173	19	4	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-11710	BRDT	up-regulates	MAF	activates	R-184	19	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13967	REM1	up-regulates	MAF	activates	R-180	19	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-14525	GPR112	up-regulates	MAF	activates	R-189	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14872	COL6A2	up-regulates	MAF	activates	R-173	19	1	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-15258	HCN1	up-regulates	MAF	activates	R-185	19	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-15367	DSE	up-regulates	MAF	activates	R-177	19	6	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-15369	DSE	up-regulates	MAF	activates	R-184	19	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15370	DSE	up-regulates	MAF	activates	R-173	19	6	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-15371	DSE	up-regulates	MAF	activates	R-176	19	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DIPYRIDAMOLE
CMF-16032	NFIX	up-regulates	MAF	activates	R-174	19	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-16034	NFIX	up-regulates	MAF	activates	R-173	19	7	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-16035	NFIX	up-regulates	MAF	activates	R-178	19	7	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-16037	NFIX	up-regulates	MAF	activates	R-189	19	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16743	CPNE8	up-regulates	MAF	activates	R-174	19	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-16744	CPNE8	up-regulates	MAF	activates	R-173	19	6	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-16745	CPNE8	up-regulates	MAF	activates	R-178	19	6	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-17139	CDH18	up-regulates	MAF	activates	R-185	19	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-17140	CDH18	up-regulates	MAF	activates	R-184	19	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17143	CDH18	up-regulates	MAF	activates	R-179	19	5	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-17288	SYNJ2	up-regulates	MAF	activates	R-185	19	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-17289	SYNJ2	up-regulates	MAF	activates	R-184	19	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17290	SYNJ2	up-regulates	MAF	activates	R-173	19	5	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-17291	SYNJ2	up-regulates	MAF	activates	R-178	19	5	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-18193	CDH19	up-regulates	MAF	activates	R-176	19	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DIPYRIDAMOLE
CMF-19190	CNTN6	up-regulates	MAF	activates	R-189	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19734	BVES	up-regulates	MAF	activates	R-175	19	3	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-19735	BVES	up-regulates	MAF	activates	R-179	19	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-19813	OR6C75	up-regulates	MAF	activates	R-173	19	1	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-20108	TDRD9	up-regulates	MAF	activates	R-174	19	9	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-20109	TDRD9	up-regulates	MAF	activates	R-180	19	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-20110	TDRD9	up-regulates	MAF	activates	R-184	19	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20111	TDRD9	up-regulates	MAF	activates	R-175	19	9	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-20112	TDRD9	up-regulates	MAF	activates	R-173	19	9	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-20116	TDRD9	up-regulates	MAF	activates	R-189	19	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21018	KRTAP4-7	up-regulates	MAF	activates	R-177	19	9	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-21019	KRTAP4-7	up-regulates	MAF	activates	R-185	19	9	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-21021	KRTAP4-7	up-regulates	MAF	activates	R-174	19	9	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-21022	KRTAP4-7	up-regulates	MAF	activates	R-180	19	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-21023	KRTAP4-7	up-regulates	MAF	activates	R-175	19	9	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-21024	KRTAP4-7	up-regulates	MAF	activates	R-178	19	9	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-21025	KRTAP4-7	up-regulates	MAF	activates	R-183	19	9	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG
CMF-21026	KRTAP4-7	up-regulates	MAF	activates	R-179	19	9	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-21250	EGR1	up-regulates	MAF	activates	R-185	19	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-21251	EGR1	up-regulates	MAF	activates	R-178	19	3	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-23073	PDHA2	down-regulates	MAF	activates	R-174	19	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-23074	PDHA2	down-regulates	MAF	activates	R-183	19	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG
CMF-24313	SMCHD1	up-regulates	MAF	activates	R-185	19	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-24314	SMCHD1	up-regulates	MAF	activates	R-184	19	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24315	SMCHD1	up-regulates	MAF	activates	R-173	19	5	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-24593	THADA	down-regulates	MAF	activates	R-179	19	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-24782	HIST1H2BE	up-regulates	MAF	activates	R-177	19	2	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME
CMF-26384	MAGEB1	down-regulates	MAF	activates	R-180	19	1	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-26574	NAALADL1	up-regulates	MAF	activates	R-174	19	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-26575	NAALADL1	up-regulates	MAF	activates	R-175	19	7	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-26576	NAALADL1	up-regulates	MAF	activates	R-173	19	7	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-26577	NAALADL1	up-regulates	MAF	activates	R-178	19	7	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) SCH-708980, MEDI-5117, CLAZAKIZUMAB, OLOKIZUMAB, SILTUXIMAB, MRA 003 US, PF-04236921, SIRUKUMAB, ZILTIVEKIMAB
CMF-26578	NAALADL1	up-regulates	MAF	activates	R-176	19	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DIPYRIDAMOLE
CMF-27437	SDK1	up-regulates	MAF	activates	R-184	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27438	SDK1	up-regulates	MAF	activates	R-173	19	2	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-29181	AQP10	down-regulates	MAF	activates	R-185	19	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-29182	AQP10	down-regulates	MAF	activates	R-174	19	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-29183	AQP10	down-regulates	MAF	activates	R-180	19	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-29184	AQP10	down-regulates	MAF	activates	R-175	19	6	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-29185	AQP10	down-regulates	MAF	activates	R-183	19	6	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) ALPROSTADIL, DINOPROSTONE, EVATANEPAG, OMIDENEPAG
CMF-29186	AQP10	down-regulates	MAF	activates	R-179	19	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-29407	EPHA8	up-regulates	MAF	activates	R-175	19	2	Drugs (4) Regulator Drugs (0) Regulon Drugs (4) CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, RECOMBINANT HUMAN INTERLEUKIN-15
CMF-29408	EPHA8	up-regulates	MAF	activates	R-189	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31312	CLASS_I_PI3K_SIGNALING_EVENTS	up-regulates	MAF	activates	R-173	19	2	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-31446	SIGNALING_EVENTS_MEDIATED_BY_TCPTP	up-regulates	MAF	activates	R-184	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31646	PDGFR_BETA_SIGNALING_PATHWAY	up-regulates	MAF	activates	R-173	19	3	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-32076	A6B1_AND_A6B4_INTEGRIN_SIGNALING	up-regulates	MAF	activates	R-185	19	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-32077	A6B1_AND_A6B4_INTEGRIN_SIGNALING	up-regulates	MAF	activates	R-180	19	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN
CMF-32078	A6B1_AND_A6B4_INTEGRIN_SIGNALING	up-regulates	MAF	activates	R-184	19	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32497	CXCR4_MEDIATED_SIGNALING_EVENTS	up-regulates	MAF	activates	R-173	19	3	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-32586	IL23_MEDIATED_SIGNALING_EVENTS	up-regulates	MAF	activates	R-189	19	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32659	EGFR_DEPENDENT_ENDOTHELIN_SIGNALING_EVENTS	up-regulates	MAF	activates	R-184	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32714	SYNDECAN_3_MEDIATED_SIGNALING_EVENTS	up-regulates	MAF	activates	R-184	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32786	E_CADHERIN_SIGNALING_IN_KERATINOCYTES	up-regulates	MAF	activates	R-185	19	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-32846	ERBB_RECEPTOR_SIGNALING_NETWORK	up-regulates	MAF	activates	R-184	19	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33312	ERBB1_DOWNSTREAM_SIGNALING	up-regulates	MAF	activates	R-185	19	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) DANVATIRSEN
CMF-33313	ERBB1_DOWNSTREAM_SIGNALING	up-regulates	MAF	activates	R-184	19	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33679	BCR_SIGNALING_PATHWAY	up-regulates	MAF	activates	R-173	19	2	Drugs (89) Regulator Drugs (0) Regulon Drugs (89) PF-04691502, FOSTAMATINIB DISODIUM, INFLIXIMAB, UMBRALISIB, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, R-348, PEGSUNERCEPT, GOLIMUMAB, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, CERDULATINIB, DUVELISIB, L19TNFA, EFALIZUMAB, DACTOLISIB, ZANDELISIB, HMPL-523, ETANERCEPT, AZD-8186, GNF-Pf-5468, WX-037, AFELIMOMAB, OZORALIZUMAB, PILARALISIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, CCX354, TASELISIB, L19SIP 131I, AMG-319, COPANLISIB HYDROCHLORIDE, TENALISIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, AZD4818, FIMEPINOSTAT, ENTOSPLETINIB, R-333, GUSACITINIB, REMTOLUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, LIFITEGRAST, ACALISIB, MIVAVOTINIB CITRATE, VELIFLAPON, BMS-817399, OCRIPLASMIN, CAL-263, ERITORAN, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, PA-799, PLACULUMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, SF-1126, FIBOFLAPON, PANULISIB
CMF-33712	IL6_MEDIATED_SIGNALING_EVENTS	up-regulates	MAF	activates	R-189	19	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

MAF - MAF bZIP transcription factor

Function

Causal Mechanistic Flows with ENSG00000178573 as Regulator

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