Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
GBX2 - gastrulation brain homeobox 2
Function
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2637 | ENSG00000168505 | GBX2 | P52951 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000168505 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00698 | HMCN1 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00699 | HMCN1 | down-regulates | GBX2 | represses | R-2082 | 7 | 3 | Drugs (1) |
| CMF-00700 | HMCN1 | down-regulates | GBX2 | represses | R-2080 | 7 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-01134 | ZNF292 | up-regulates | GBX2 | represses | R-2078 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-01273 | KRT37 | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02325 | ERG | down-regulates | GBX2 | represses | R-2078 | 7 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-02836 | MST1 | down-regulates | GBX2 | represses | R-2082 | 7 | 2 | Drugs (1) |
| CMF-04301 | RBPJL | down-regulates | GBX2 | represses | R-2078 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-06503 | RPL23AP32 | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07073 | ATRX | up-regulates | GBX2 | represses | R-2084 | 7 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07074 | ATRX | up-regulates | GBX2 | represses | R-2082 | 7 | 5 | Drugs (1) |
| CMF-07075 | ATRX | up-regulates | GBX2 | represses | R-2078 | 7 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-07077 | ATRX | up-regulates | GBX2 | represses | R-2080 | 7 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-07678 | SAMD9L | up-regulates | GBX2 | represses | R-2082 | 7 | 1 | Drugs (1) |
| CMF-08296 | KIF4A | up-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08651 | SLC4A7 | down-regulates | GBX2 | represses | R-2078 | 7 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-10419 | ZAN | down-regulates | GBX2 | represses | R-2078 | 7 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-10475 | GLIS1 | down-regulates | GBX2 | represses | R-2082 | 7 | 1 | Drugs (1) |
| CMF-11022 | BMP5 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11023 | BMP5 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-11115 | ATF7IP2 | down-regulates | GBX2 | represses | R-2084 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11116 | ATF7IP2 | down-regulates | GBX2 | represses | R-2078 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-11898 | PALM2-AKAP2 | down-regulates | GBX2 | represses | R-2084 | 7 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11899 | PALM2-AKAP2 | down-regulates | GBX2 | represses | R-2082 | 7 | 4 | Drugs (1) |
| CMF-11900 | PALM2-AKAP2 | down-regulates | GBX2 | represses | R-2078 | 7 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-11901 | PALM2-AKAP2 | down-regulates | GBX2 | represses | R-2080 | 7 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-12392 | MAST4 | down-regulates | GBX2 | represses | R-2084 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13737 | TUBA3C | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15293 | HCN1 | down-regulates | GBX2 | represses | R-2082 | 7 | 1 | Drugs (1) |
| CMF-15447 | DSE | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15448 | DSE | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-15744 | FN1 | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16485 | SUSD5 | down-regulates | GBX2 | represses | R-2084 | 7 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16486 | SUSD5 | down-regulates | GBX2 | represses | R-2078 | 7 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-17437 | LGALS8 | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18501 | LAMA1 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18502 | LAMA1 | down-regulates | GBX2 | represses | R-2082 | 7 | 3 | Drugs (1) |
| CMF-18503 | LAMA1 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-19530 | NF1 | down-regulates | GBX2 | represses | R-2082 | 7 | 6 | Drugs (1) |
| CMF-19531 | NF1 | down-regulates | GBX2 | represses | R-2078 | 7 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-19534 | NF1 | down-regulates | GBX2 | represses | R-2080 | 7 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-19784 | BVES | down-regulates | GBX2 | represses | R-2078 | 7 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20317 | FREM1 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20318 | FREM1 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-21188 | ATM | down-regulates | GBX2 | represses | R-2084 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22843 | IDH1 | up-regulates | GBX2 | represses | R-2084 | 7 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22844 | IDH1 | up-regulates | GBX2 | represses | R-2082 | 7 | 5 | Drugs (1) |
| CMF-22845 | IDH1 | up-regulates | GBX2 | represses | R-2078 | 7 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-22847 | IDH1 | up-regulates | GBX2 | represses | R-2080 | 7 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-23276 | RNF17 | down-regulates | GBX2 | represses | R-2084 | 7 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23992 | TP53 | up-regulates | GBX2 | represses | R-2084 | 7 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23994 | TP53 | up-regulates | GBX2 | represses | R-2082 | 7 | 6 | Drugs (1) |
| CMF-23995 | TP53 | up-regulates | GBX2 | represses | R-2078 | 7 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-23997 | TP53 | up-regulates | GBX2 | represses | R-2080 | 7 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-25470 | PCDHGB3 | down-regulates | GBX2 | represses | R-2082 | 7 | 1 | Drugs (1) |
| CMF-25797 | FZD10 | up-regulates | GBX2 | represses | R-2082 | 7 | 1 | Drugs (1) |
| CMF-26017 | CTNNA2 | down-regulates | GBX2 | represses | R-2078 | 7 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-27052 | DNAH5 | down-regulates | GBX2 | represses | R-2084 | 7 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27053 | DNAH5 | down-regulates | GBX2 | represses | R-2078 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-27345 | CHD5 | down-regulates | GBX2 | represses | R-2084 | 7 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27347 | CHD5 | down-regulates | GBX2 | represses | R-2078 | 7 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-27348 | CHD5 | down-regulates | GBX2 | represses | R-2080 | 7 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-28110 | CELSR3 | up-regulates | GBX2 | represses | R-2082 | 7 | 2 | Drugs (1) |
| CMF-28111 | CELSR3 | up-regulates | GBX2 | represses | R-2080 | 7 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |
| CMF-30267 | RAB3GAP2 | down-regulates | GBX2 | represses | R-2084 | 7 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |