Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

IRF8 - interferon regulatory factor 8

Function

Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
3394	ENSG00000140968	IRF8	Q02556

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000140968 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00253	CDC27	down-regulates	IRF8	activates	R-398	18	1	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB
CMF-00402	ZNF99	up-regulates	IRF8	activates	R-397	18	2	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-00862	MUC2	up-regulates	IRF8	activates	R-411	18	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-04303	RBPJL	up-regulates	IRF8	activates	R-411	18	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-04304	RBPJL	up-regulates	IRF8	activates	R-406	18	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04306	RBPJL	up-regulates	IRF8	activates	R-398	18	6	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB
CMF-04307	RBPJL	up-regulates	IRF8	activates	R-403	18	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04308	RBPJL	up-regulates	IRF8	activates	R-397	18	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-04371	LILRB1	up-regulates	IRF8	activates	R-397	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-06538	SETD2	down-regulates	IRF8	activates	R-396	18	4	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-06539	SETD2	down-regulates	IRF8	activates	R-403	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06540	SETD2	down-regulates	IRF8	activates	R-409	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06617	CACNA1D	down-regulates	IRF8	activates	R-410	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07591	AHNAK2	down-regulates	IRF8	activates	R-410	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-07592	AHNAK2	down-regulates	IRF8	activates	R-396	18	4	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-07593	AHNAK2	down-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-07594	AHNAK2	down-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-08933	DIAPH2	down-regulates	IRF8	activates	R-410	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08935	DIAPH2	down-regulates	IRF8	activates	R-409	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11437	CYP4F22	up-regulates	IRF8	activates	R-411	18	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-11438	CYP4F22	up-regulates	IRF8	activates	R-396	18	7	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-11439	CYP4F22	up-regulates	IRF8	activates	R-403	18	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11440	CYP4F22	up-regulates	IRF8	activates	R-397	18	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-11442	CYP4F22	up-regulates	IRF8	activates	R-395	18	7	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-13855	ADAMTS8	down-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-13856	ADAMTS8	down-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-13857	ADAMTS8	down-regulates	IRF8	activates	R-405	18	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OBATOCLAX MESYLATE, OBATOCLAX
CMF-14383	NR3C2	up-regulates	IRF8	activates	R-411	18	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-14643	C1orf177	up-regulates	IRF8	activates	R-395	18	2	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-14764	SLC5A12	up-regulates	IRF8	activates	R-398	18	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB
CMF-14765	SLC5A12	up-regulates	IRF8	activates	R-403	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14767	SLC5A12	up-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-14882	COL6A2	up-regulates	IRF8	activates	R-395	18	1	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-15182	FAM110B	down-regulates	IRF8	activates	R-397	18	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-15226	OR51F1	down-regulates	IRF8	activates	R-396	18	8	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-15227	OR51F1	down-regulates	IRF8	activates	R-403	18	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15228	OR51F1	down-regulates	IRF8	activates	R-397	18	8	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-15230	OR51F1	down-regulates	IRF8	activates	R-395	18	8	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-15231	OR51F1	down-regulates	IRF8	activates	R-405	18	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) OBATOCLAX MESYLATE, OBATOCLAX
CMF-15497	ZFP57	down-regulates	IRF8	activates	R-395	18	1	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-15867	ZNF845	down-regulates	IRF8	activates	R-409	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-15868	ZNF845	down-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-15869	ZNF845	down-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-18927	TEAD1	down-regulates	IRF8	activates	R-409	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19669	RPSAP58	up-regulates	IRF8	activates	R-406	18	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19672	RPSAP58	up-regulates	IRF8	activates	R-397	18	5	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-19673	RPSAP58	up-regulates	IRF8	activates	R-395	18	5	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-27236	PCDH11X	down-regulates	IRF8	activates	R-395	18	1	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-28742	SYN3	down-regulates	IRF8	activates	R-398	18	4	Drugs (8) Regulator Drugs (0) Regulon Drugs (8) ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB
CMF-28743	SYN3	down-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-28744	SYN3	down-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-29702	ESRRB	up-regulates	IRF8	activates	R-411	18	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NI-0801, ELDELUMAB
CMF-29703	ESRRB	up-regulates	IRF8	activates	R-396	18	4	Drugs (9) Regulator Drugs (0) Regulon Drugs (9) OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, BELNACASAN, IXAZOMIB CITRATE, CARFILZOMIB
CMF-29705	ESRRB	up-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-30118	GRIP1	down-regulates	IRF8	activates	R-403	18	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30271	RAB3GAP2	up-regulates	IRF8	activates	R-397	18	3	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-31183	LRFN2	down-regulates	IRF8	activates	R-410	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31185	LRFN2	down-regulates	IRF8	activates	R-397	18	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL
CMF-31186	LRFN2	down-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-31340	CLASS_I_PI3K_SIGNALING_EVENTS	up-regulates	IRF8	activates	R-403	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31341	CLASS_I_PI3K_SIGNALING_EVENTS	up-regulates	IRF8	activates	R-395	18	3	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-31700	PDGFR_BETA_SIGNALING_PATHWAY	up-regulates	IRF8	activates	R-403	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31701	PDGFR_BETA_SIGNALING_PATHWAY	up-regulates	IRF8	activates	R-395	18	4	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-32537	CXCR4_MEDIATED_SIGNALING_EVENTS	up-regulates	IRF8	activates	R-403	18	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32541	CXCR4_MEDIATED_SIGNALING_EVENTS	up-regulates	IRF8	activates	R-395	18	7	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB
CMF-32607	IL23_MEDIATED_SIGNALING_EVENTS	up-regulates	IRF8	activates	R-403	18	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32905	EPHA2_FORWARD_SIGNALING	up-regulates	IRF8	activates	R-403	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32906	EPHA2_FORWARD_SIGNALING	up-regulates	IRF8	activates	R-409	18	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33254	EPHRIN_B_REVERSE_SIGNALING	up-regulates	IRF8	activates	R-403	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33255	EPHRIN_B_REVERSE_SIGNALING	up-regulates	IRF8	activates	R-409	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33695	BCR_SIGNALING_PATHWAY	up-regulates	IRF8	activates	R-403	18	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-33697	BCR_SIGNALING_PATHWAY	up-regulates	IRF8	activates	R-395	18	3	Drugs (75) Regulator Drugs (0) Regulon Drugs (75) PF-04691502, PICOTAMIDE, BGT-226, SONOLISIB, TERBOGREL, VOXTALISIB, BMS-986142, HM-71224, APITOLISIB, DASATINIB, DS-7423, L19IL2, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, PF-06651600, ABIVERTINIB, ABIVERTINIB MALEATE, MEDI-2338, VS-5584, SAMOTOLISIB, VOBARILIZUMAB, L19TNFA, DACTOLISIB, BOSUTINIB, TOCILIZUMAB, GNF-Pf-5468, WX-037, RILZABRUTINIB, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, TASELISIB, L19SIP 131I, IBRUTINIB, TADEKINIG ALFA, PETESICATIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, NEIHULIZUMAB, ENTOLIMOD, ZANUBRUTINIB, XL-228, SATRALIZUMAB, EVOBRUTINIB, OTLERTUZUMAB, BI-836826, ERITORAN TETRASODIUM, TOMIVOSERTIB, TG100-801, SPEBRUTINIB BESYLATE, POSELTINIB, PIRTOBRUTINIB, OCRIPLASMIN, ACALABRUTINIB, ERITORAN, ELSUBRUTINIB, BRANEBRUTINIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, ENMD-981693, PANULISIB

IRF8 - interferon regulatory factor 8

Function

Causal Mechanistic Flows with ENSG00000140968 as Regulator

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