Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IRF4 - interferon regulatory factor 4
Function
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3662 | ENSG00000137265 | IRF4 | Q15306 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000137265 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03997 | DSP | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-05321 | PCSK6 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-06231 | GABRB2 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-08842 | FBLN2 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-09384 | CUL1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-11270 | OR5W2 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-14948 | SDHAP3 | down-regulates | IRF4 | represses | R-3772 | 5 | 3 | Drugs (1) |
| CMF-16484 | SUSD5 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-17118 | RERE | down-regulates | IRF4 | represses | R-3772 | 5 | 3 | Drugs (1) |
| CMF-21919 | PRAME | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-23275 | RNF17 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-24271 | SIM1 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-25692 | MUC4 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-27149 | SLC44A5 | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |
| CMF-29038 | OR51T1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-30840 | RYR1 | down-regulates | IRF4 | represses | R-3772 | 5 | 2 | Drugs (1) |
| CMF-33462 | TCR_SIGNALING_IN_NAIVE_CD4+_T_CELLS | down-regulates | IRF4 | represses | R-3772 | 5 | 1 | Drugs (1) |