Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IRF5 - interferon regulatory factor 5
Function
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3663 | ENSG00000128604 | IRF5 | Q13568 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000128604 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03242 | OBSCN | down-regulates | IRF5 | activates | R-1083 | 11 | 1 | Drugs (3) |
| CMF-04544 | LAMC3 | down-regulates | IRF5 | activates | R-1089 | 11 | 3 | Drugs (3) |
| CMF-05203 | ZFYVE26 | down-regulates | IRF5 | activates | R-1083 | 11 | 3 | Drugs (3) |
| CMF-05204 | ZFYVE26 | down-regulates | IRF5 | activates | R-1089 | 11 | 3 | Drugs (3) |
| CMF-05205 | ZFYVE26 | down-regulates | IRF5 | activates | R-1091 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07828 | TNK2 | down-regulates | IRF5 | activates | R-1083 | 11 | 2 | Drugs (3) |
| CMF-07829 | TNK2 | down-regulates | IRF5 | activates | R-1089 | 11 | 2 | Drugs (3) |
| CMF-10051 | ATP8A2 | down-regulates | IRF5 | activates | R-1085 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10052 | ATP8A2 | down-regulates | IRF5 | activates | R-1089 | 11 | 3 | Drugs (3) |
| CMF-13908 | HRH2 | up-regulates | IRF5 | activates | R-1091 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14034 | CEACAM20 | down-regulates | IRF5 | activates | R-1083 | 11 | 2 | Drugs (3) |
| CMF-15947 | KCNB2 | up-regulates | IRF5 | activates | R-1083 | 11 | 1 | Drugs (3) |
| CMF-17110 | RERE | up-regulates | IRF5 | activates | R-1083 | 11 | 3 | Drugs (3) |
| CMF-17996 | PRPF40B | down-regulates | IRF5 | activates | R-1085 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18879 | INPP5J | down-regulates | IRF5 | activates | R-1089 | 11 | 2 | Drugs (3) |
| CMF-19695 | UGT2B4 | up-regulates | IRF5 | activates | R-1089 | 11 | 3 | Drugs (3) |
| CMF-21047 | KRTAP4-7 | up-regulates | IRF5 | activates | R-1085 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21048 | KRTAP4-7 | up-regulates | IRF5 | activates | R-1089 | 11 | 3 | Drugs (3) |
| CMF-27689 | FAM83H | down-regulates | IRF5 | activates | R-1083 | 11 | 3 | Drugs (3) |
| CMF-27690 | FAM83H | down-regulates | IRF5 | activates | R-1091 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28027 | AMPD1 | up-regulates | IRF5 | activates | R-1091 | 11 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |