Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

IRF3 - interferon regulatory factor 3

Function

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:24049179, PubMed:31340999). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591). In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
3661	ENSG00000126456	IRF3	Q14653

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000126456 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00200	PCLO	up-regulates	IRF3	activates	R-2441	25	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-00651	HMCN1	up-regulates	IRF3	activates	R-2426	25	13	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-00652	HMCN1	up-regulates	IRF3	activates	R-2438	25	13	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-00654	HMCN1	up-regulates	IRF3	activates	R-2429	25	13	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-00655	HMCN1	up-regulates	IRF3	activates	R-2446	25	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-00658	HMCN1	up-regulates	IRF3	activates	R-2449	25	13	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-00659	HMCN1	up-regulates	IRF3	activates	R-2441	25	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-00660	HMCN1	up-regulates	IRF3	activates	R-2427	25	13	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-00661	HMCN1	up-regulates	IRF3	activates	R-2431	25	13	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-00662	HMCN1	up-regulates	IRF3	activates	R-2430	25	13	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-00990	TPTE	up-regulates	IRF3	activates	R-2426	25	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-00991	TPTE	up-regulates	IRF3	activates	R-2438	25	7	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-00992	TPTE	up-regulates	IRF3	activates	R-2446	25	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-01222	IRAK3	down-regulates	IRF3	activates	R-2429	25	4	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-01224	IRAK3	down-regulates	IRF3	activates	R-2427	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-03206	RFX6	up-regulates	IRF3	activates	R-2441	25	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-04571	LAMC3	down-regulates	IRF3	activates	R-2446	25	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-04572	LAMC3	down-regulates	IRF3	activates	R-2449	25	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-04573	LAMC3	down-regulates	IRF3	activates	R-2430	25	3	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-05384	KDELC2	up-regulates	IRF3	activates	R-2429	25	8	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-05385	KDELC2	up-regulates	IRF3	activates	R-2446	25	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-05386	KDELC2	up-regulates	IRF3	activates	R-2437	25	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05391	KDELC2	up-regulates	IRF3	activates	R-2427	25	8	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-06258	ELTD1	up-regulates	IRF3	activates	R-2427	25	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-06994	ATRX	down-regulates	IRF3	activates	R-2426	25	17	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-06995	ATRX	down-regulates	IRF3	activates	R-2438	25	17	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-06997	ATRX	down-regulates	IRF3	activates	R-2429	25	17	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-06998	ATRX	down-regulates	IRF3	activates	R-2446	25	17	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-07001	ATRX	down-regulates	IRF3	activates	R-2449	25	17	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-07002	ATRX	down-regulates	IRF3	activates	R-2441	25	17	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-07007	ATRX	down-regulates	IRF3	activates	R-2427	25	17	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-07008	ATRX	down-regulates	IRF3	activates	R-2431	25	17	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-07009	ATRX	down-regulates	IRF3	activates	R-2430	25	17	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-07432	THOC2	up-regulates	IRF3	activates	R-2429	25	4	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-07433	THOC2	up-regulates	IRF3	activates	R-2446	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-07434	THOC2	up-regulates	IRF3	activates	R-2437	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10977	BMP5	up-regulates	IRF3	activates	R-2426	25	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-10978	BMP5	up-regulates	IRF3	activates	R-2437	25	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10983	BMP5	up-regulates	IRF3	activates	R-2427	25	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-11137	MYO18A	down-regulates	IRF3	activates	R-2438	25	4	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-11139	MYO18A	down-regulates	IRF3	activates	R-2449	25	4	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-11639	GPR133	down-regulates	IRF3	activates	R-2429	25	2	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-11729	BRDT	up-regulates	IRF3	activates	R-2446	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-11963	CENPE	up-regulates	IRF3	activates	R-2441	25	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-12076	NOX3	up-regulates	IRF3	activates	R-2437	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-12078	NOX3	up-regulates	IRF3	activates	R-2427	25	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-12591	CD22	up-regulates	IRF3	activates	R-2427	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-12723	SIN3A	down-regulates	IRF3	activates	R-2449	25	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-13526	FMN1	up-regulates	IRF3	activates	R-2437	25	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13529	FMN1	up-regulates	IRF3	activates	R-2441	25	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-13829	ADAMTS8	down-regulates	IRF3	activates	R-2438	25	3	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-13830	ADAMTS8	down-regulates	IRF3	activates	R-2449	25	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-14254	APOBEC1	up-regulates	IRF3	activates	R-2427	25	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-14922	SDHAP3	up-regulates	IRF3	activates	R-2438	25	6	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-14923	SDHAP3	up-regulates	IRF3	activates	R-2446	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-14924	SDHAP3	up-regulates	IRF3	activates	R-2437	25	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14926	SDHAP3	up-regulates	IRF3	activates	R-2431	25	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-15953	KCNB2	up-regulates	IRF3	activates	R-2429	25	1	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-16456	SUSD5	up-regulates	IRF3	activates	R-2426	25	7	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-16458	SUSD5	up-regulates	IRF3	activates	R-2429	25	7	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-16462	SUSD5	up-regulates	IRF3	activates	R-2431	25	7	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-16784	MACF1	down-regulates	IRF3	activates	R-2438	25	6	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-16785	MACF1	down-regulates	IRF3	activates	R-2446	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-16787	MACF1	down-regulates	IRF3	activates	R-2427	25	6	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-16788	MACF1	down-regulates	IRF3	activates	R-2431	25	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-16789	MACF1	down-regulates	IRF3	activates	R-2430	25	6	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-16942	TIE1	up-regulates	IRF3	activates	R-2438	25	1	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-18229	CDH19	up-regulates	IRF3	activates	R-2437	25	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18235	CDH19	up-regulates	IRF3	activates	R-2427	25	7	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-18707	MPP7	down-regulates	IRF3	activates	R-2426	25	10	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-18708	MPP7	down-regulates	IRF3	activates	R-2438	25	10	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-18709	MPP7	down-regulates	IRF3	activates	R-2446	25	10	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-18714	MPP7	down-regulates	IRF3	activates	R-2427	25	10	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-18715	MPP7	down-regulates	IRF3	activates	R-2431	25	10	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-18716	MPP7	down-regulates	IRF3	activates	R-2430	25	10	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-21525	KLHL34	down-regulates	IRF3	activates	R-2426	25	4	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-21768	COL1A2	up-regulates	IRF3	activates	R-2437	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21770	COL1A2	up-regulates	IRF3	activates	R-2427	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-22154	PDGFRA	down-regulates	IRF3	activates	R-2449	25	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-22155	PDGFRA	down-regulates	IRF3	activates	R-2430	25	2	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-22697	IDH1	down-regulates	IRF3	activates	R-2426	25	20	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-22699	IDH1	down-regulates	IRF3	activates	R-2438	25	20	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-22701	IDH1	down-regulates	IRF3	activates	R-2429	25	20	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-22702	IDH1	down-regulates	IRF3	activates	R-2446	25	20	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-22703	IDH1	down-regulates	IRF3	activates	R-2437	25	20	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22706	IDH1	down-regulates	IRF3	activates	R-2449	25	20	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-22707	IDH1	down-regulates	IRF3	activates	R-2441	25	20	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-22712	IDH1	down-regulates	IRF3	activates	R-2427	25	20	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-22713	IDH1	down-regulates	IRF3	activates	R-2431	25	20	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-22714	IDH1	down-regulates	IRF3	activates	R-2430	25	20	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-23873	TP53	down-regulates	IRF3	activates	R-2426	25	18	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-23874	TP53	down-regulates	IRF3	activates	R-2438	25	18	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-23875	TP53	down-regulates	IRF3	activates	R-2429	25	18	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-23876	TP53	down-regulates	IRF3	activates	R-2446	25	18	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB
CMF-23877	TP53	down-regulates	IRF3	activates	R-2437	25	18	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23881	TP53	down-regulates	IRF3	activates	R-2449	25	18	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-23886	TP53	down-regulates	IRF3	activates	R-2427	25	18	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-23887	TP53	down-regulates	IRF3	activates	R-2431	25	18	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-23888	TP53	down-regulates	IRF3	activates	R-2430	25	18	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-24340	SMCHD1	up-regulates	IRF3	activates	R-2429	25	4	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-24342	SMCHD1	up-regulates	IRF3	activates	R-2441	25	4	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-24343	SMCHD1	up-regulates	IRF3	activates	R-2430	25	4	Drugs (6) Regulator Drugs (0) Regulon Drugs (6) DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM
CMF-24773	PPP1R3A	down-regulates	IRF3	activates	R-2427	25	4	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-24903	MGAT4C	up-regulates	IRF3	activates	R-2437	25	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-25201	ZNF534	up-regulates	IRF3	activates	R-2441	25	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-25203	ZNF534	up-regulates	IRF3	activates	R-2427	25	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-28087	CELSR3	down-regulates	IRF3	activates	R-2426	25	6	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-28089	CELSR3	down-regulates	IRF3	activates	R-2438	25	6	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-28090	CELSR3	down-regulates	IRF3	activates	R-2449	25	6	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, MIFAMURTIDE, PEFCALCITOL, LUNACALCIPOL, TOSEDOSTAT, DP001, ALFACALCIDOL
CMF-28092	CELSR3	down-regulates	IRF3	activates	R-2431	25	6	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-28302	PIK3C2B	up-regulates	IRF3	activates	R-2429	25	2	Drugs (12) Regulator Drugs (0) Regulon Drugs (12) OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB
CMF-28303	PIK3C2B	up-regulates	IRF3	activates	R-2427	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-28626	ARHGAP28	down-regulates	IRF3	activates	R-2426	25	1	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-28777	MLL4	down-regulates	IRF3	activates	R-2438	25	5	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-28778	MLL4	down-regulates	IRF3	activates	R-2437	25	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28780	MLL4	down-regulates	IRF3	activates	R-2427	25	5	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TOSEDOSTAT
CMF-28781	MLL4	down-regulates	IRF3	activates	R-2431	25	5	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) ANG1005, PROBUCOL
CMF-30299	MSR1	up-regulates	IRF3	activates	R-2441	25	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-30690	ABCA13	down-regulates	IRF3	activates	R-2426	25	8	Drugs (16) Regulator Drugs (0) Regulon Drugs (16) ATN-161, TAS0612, LANATOSIDE C, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, DESLANOSIDE, ISTAROXIME, ABITUZUMAB
CMF-30692	ABCA13	down-regulates	IRF3	activates	R-2438	25	8	Drugs (7) Regulator Drugs (0) Regulon Drugs (7) DICHLORPHENAMIDE, ALEPLASININ, SULTHIAME, ACETAZOLAMIDE, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, ACETAZOLAMIDE SODIUM
CMF-30694	ABCA13	down-regulates	IRF3	activates	R-2441	25	8	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) MARIMASTAT, TOSEDOSTAT
CMF-30951	COL3A1	up-regulates	IRF3	activates	R-2446	25	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BIVATUZUMAB

IRF3 - interferon regulatory factor 3

Function

Causal Mechanistic Flows with ENSG00000126456 as Regulator

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