Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ZBTB16 - zinc finger and BTB domain containing 16
Function
Acts as a transcriptional repressor (PubMed:10688654, PubMed:24359566). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters (PubMed:10688654). May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7704 | ENSG00000109906 | ZBTB16 | Q05516 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000109906 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00031 | LRP2 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 3 | Drugs (4) |
| CMF-04390 | ATP8B3 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-07951 | F5 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-16983 | CHRM2 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 1 | Drugs (4) |
| CMF-18729 | ARHGAP21 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-24281 | SMCHD1 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 3 | Drugs (4) |
| CMF-24437 | SEMA3C | down-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-24830 | SULT1B1 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-25927 | PRKG2 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 1 | Drugs (4) |
| CMF-27011 | DNAH5 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-27072 | NBAS | up-regulates | ZBTB16 | activates | R-2185 | 16 | 3 | Drugs (4) |
| CMF-28699 | TRPS1 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 2 | Drugs (4) |
| CMF-29756 | SLC5A7 | up-regulates | ZBTB16 | activates | R-2185 | 16 | 4 | Drugs (4) |