Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
GATA3 - GATA binding protein 3
Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2625 | ENSG00000107485 | GATA3 | P23771 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000107485 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02193 | ANO1 | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-04476 | MYH8 | up-regulates | GATA3 | activates | R-3096 | 7 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-05352 | AMAC1 | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |
| CMF-06396 | FAT3 | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |
| CMF-06507 | C2orf89 | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |
| CMF-06543 | SETD2 | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-07140 | ATRX | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-07144 | ATRX | down-regulates | GATA3 | represses | R-3102 | 7 | 5 | Drugs (5) |
| CMF-07646 | MYH9 | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-08544 | MYO3A | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |
| CMF-08624 | LOC401010 | down-regulates | GATA3 | activates | R-3096 | 7 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-10371 | FGG | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-11808 | DNAH17 | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-14505 | PRKCD | down-regulates | GATA3 | activates | R-3096 | 7 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-19557 | NF1 | up-regulates | GATA3 | activates | R-3096 | 7 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-19562 | NF1 | up-regulates | GATA3 | represses | R-3102 | 7 | 6 | Drugs (5) |
| CMF-22931 | IDH1 | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-22935 | IDH1 | down-regulates | GATA3 | represses | R-3102 | 7 | 5 | Drugs (5) |
| CMF-25353 | PARG | down-regulates | GATA3 | represses | R-3102 | 7 | 2 | Drugs (5) |
| CMF-27719 | FAM83H | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-27723 | FAM83H | down-regulates | GATA3 | represses | R-3102 | 7 | 5 | Drugs (5) |
| CMF-28118 | CELSR3 | down-regulates | GATA3 | activates | R-3096 | 7 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-29245 | AQP10 | down-regulates | GATA3 | activates | R-3096 | 7 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-29247 | AQP10 | down-regulates | GATA3 | represses | R-3102 | 7 | 3 | Drugs (5) |
| CMF-30253 | ACSM2B | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |
| CMF-30451 | KIAA1467 | down-regulates | GATA3 | represses | R-3102 | 7 | 1 | Drugs (5) |