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Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

RFX2 - regulatory factor X2

Function

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:10330134). Probably activates transcription of the testis-specific histone gene H1-6 (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
5990 ENSG00000087903 RFX2 P48378

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000087903 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00470TP53down-regulatesRFX2activatesR-229863Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-02318ERGup-regulatesRFX2activatesR-229861Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03591RGS12down-regulatesRFX2activatesR-229861Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-06978ATRXdown-regulatesRFX2activatesR-230064Drugs (16)
CMF-06981ATRXdown-regulatesRFX2activatesR-229864Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07431THOC2up-regulatesRFX2activatesR-230061Drugs (16)
CMF-08045ABCC4up-regulatesRFX2activatesR-230061Drugs (16)
CMF-09983MAPKBP1up-regulatesRFX2activatesR-230061Drugs (16)
CMF-12127COL6A3up-regulatesRFX2activatesR-229862Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-13041PTPN3up-regulatesRFX2activatesR-229862Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-13096CLYBLup-regulatesRFX2activatesR-229862Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15671DCHS2up-regulatesRFX2activatesR-230061Drugs (16)
CMF-17504MECOMdown-regulatesRFX2activatesR-229862Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-18406FANCMdown-regulatesRFX2activatesR-229864Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-18980MLLT4up-regulatesRFX2activatesR-229861Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22678IDH1down-regulatesRFX2activatesR-230064Drugs (16)
CMF-22681IDH1down-regulatesRFX2activatesR-229864Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-23861TP53down-regulatesRFX2activatesR-230064Drugs (16)
CMF-25153FLT3up-regulatesRFX2activatesR-230061Drugs (16)
CMF-25936PRKG2up-regulatesRFX2activatesR-230062Drugs (16)
CMF-26488EGFRup-regulatesRFX2activatesR-229861Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-29072DNAH3up-regulatesRFX2activatesR-230061Drugs (16)
CMF-29878ABCC9up-regulatesRFX2activatesR-230062Drugs (16)
CMF-31567EGF_RECEPTOR_SIGNALING_PATHWAYup-regulatesRFX2activatesR-230062Drugs (16)
CMF-33359ERBB1_DOWNSTREAM_SIGNALINGup-regulatesRFX2activatesR-230062Drugs (16)