Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NR1H4 - nuclear receptor subfamily 1 group H member 4
Function
Isoform 4Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 9971 | ENSG00000012504 | NR1H4 | Q96RI1 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000012504 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00314 | COL6A3 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01660 | MMRN1 | down-regulates | NR1H4 | represses | R-2342 | 6 | 1 | Drugs (4) |
| CMF-04901 | ABCC5 | up-regulates | NR1H4 | represses | R-2343 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05867 | ZNF813 | down-regulates | NR1H4 | represses | R-2342 | 6 | 1 | Drugs (4) |
| CMF-11100 | ATF7IP2 | down-regulates | NR1H4 | represses | R-2342 | 6 | 3 | Drugs (4) |
| CMF-11101 | ATF7IP2 | down-regulates | NR1H4 | represses | R-2343 | 6 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13419 | FMN1 | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-14325 | RIMS2 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15110 | KCNQ5 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15617 | DCHS2 | down-regulates | NR1H4 | represses | R-2343 | 6 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15943 | KCNB2 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17455 | OR5L2 | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18935 | DENND1C | down-regulates | NR1H4 | represses | R-2343 | 6 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24759 | CHAT | down-regulates | NR1H4 | represses | R-2342 | 6 | 1 | Drugs (4) |
| CMF-25911 | MMP13 | down-regulates | NR1H4 | represses | R-2342 | 6 | 1 | Drugs (4) |
| CMF-26989 | HMCN1 | down-regulates | NR1H4 | represses | R-2342 | 6 | 1 | Drugs (4) |
| CMF-30150 | MKI67 | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-31210 | ACACA | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-31518 | EGF_RECEPTOR_SIGNALING_PATHWAY | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-32072 | A6B1_AND_A6B4_INTEGRIN_SIGNALING | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-32785 | E_CADHERIN_SIGNALING_IN_KERATINOCYTES | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-33308 | ERBB1_DOWNSTREAM_SIGNALING | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |
| CMF-33789 | SIGNALING_EVENTS_MEDIATED_BY_PTP1B | down-regulates | NR1H4 | represses | R-2344 | 6 | 1 | Drugs (5) |