Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ETV7 - ETS variant transcription factor 7
Function
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor activity.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 51513 | ENSG00000010030 | ETV7 | Q9Y603 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000010030 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01713 | SGOL2 | up-regulates | ETV7 | represses | R-843 | 5 | 2 | Drugs (1) |
| CMF-04810 | SLC6A3 | up-regulates | ETV7 | represses | R-843 | 5 | 2 | Drugs (1) |
| CMF-06395 | FAT3 | down-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-07072 | ATRX | down-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-12887 | EZR | up-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-13702 | KEL | up-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-15516 | NCAPG | down-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-17825 | HERC2 | down-regulates | ETV7 | represses | R-843 | 5 | 1 | Drugs (1) |
| CMF-22842 | IDH1 | down-regulates | ETV7 | represses | R-843 | 5 | 3 | Drugs (1) |