Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ZNF814_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01648 | ZNF814 | up-regulates | NF1 | activates | R-2315 | 11 | 6 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)BEROTRALSTAT HYDROCHLORIDE, LANATOSIDE C, AVORALSTAT, APROTININ, HUMAN C1-ESTERASE INHIBITOR, DIGOXIN, ACETYLDIGITOXIN, LANADELUMAB, ECALLANTIDE, DIGITOXIN, DESLANOSIDE, BEROTRALSTAT, ISTAROXIME |
| CMF-01651 | ZNF814 | up-regulates | NF1 | represses | R-2310 | 11 | 6 | Drugs (2) |
| CMF-01652 | ZNF814 | up-regulates | NF1 | represses | R-2309 | 11 | 6 | Drugs (1) |
| CMF-01654 | ZNF814 | down-regulates | ELF3 | activates | R-3684 | 14 | 1 | Drugs (4) |
| CMF-01655 | ZNF814 | down-regulates | BACH1 | activates | R-2754 | 11 | 1 | Drugs (1) |
| CMF-34066 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2161 | 155 | 8 | Drugs (2) |
| CMF-34067 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-397 | 155 | 8 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34068 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2477 | 155 | 8 | Drugs (2) |
| CMF-34069 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2481 | 155 | 8 | Drugs (1) |
| CMF-34070 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2585 | 155 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34071 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2885 | 155 | 8 | Drugs (1) |
| CMF-34072 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-3134 | 155 | 8 | Drugs (1) |
| CMF-34073 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-1679 | 155 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34074 | ZNF814 | up-regulates | hsa-mir-331 | represses | R-2481 | 7 | 1 | Drugs (1) |