Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation KIAA2026_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04139 | KIAA2026 | up-regulates | SP4 | represses | R-2346 | 8 | 1 | Drugs (45) Regulator Drugs (0)Regulon Drugs (45)POZIOTINIB, MM-111, TRASTUZUMAB DERUXTECAN, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, TUCATINIB, HEMAY-022, MP-412, TRASTUZUMAB EMTANSINE, ZENOCUTUZUMAB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MUBRITINIB, LAPATINIB, SAPITINIB, NERATINIB, BMS-690514, AC-480, DACOMITINIB, KBP5209, TARLOXOTINIB, VANDETANIB, ALLITINIB, ERTUMAXOMAB, TRASTUZUMAB DUOCARMAZINE, MARGETUXIMAB, TRASTUZUMAB, T-DM1, CANERTINIB, BDTX189, JNJ-26483327, TESEVATINIB, JI-101, AFATINIB DIMALEATE, CP-724714, AFATINIB, TG100-801, OCRIPLASMIN, AEE-788, PYROTINIB, TAK-285, PERTUZUMAB, GSK-690693, GANCOTAMAB |
| CMF-04140 | KIAA2026 | down-regulates | LHX3 | represses | R-1995 | 24 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DINOPROSTONE, CR-6086, GRAPIPRANT, RIVENPROST, DIQUAFOSOL, DIQUAFOSOL TETRASODIUM |