Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation FLT3_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-25116FLT3up-regulatesTEAD1activatesR-2399154Drugs (11)
CMF-25117FLT3up-regulatesTEAD1activatesR-2395154Drugs (16)
CMF-25120FLT3down-regulatesNR4A2activatesR-375441Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25123FLT3up-regulatesETV6activatesR-1281Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

OCRIPLASMIN, VESENCUMAB

CMF-25126FLT3up-regulatesSOX9activatesR-1234165Drugs (16)
CMF-25129FLT3up-regulatesSOX9activatesR-1225165Drugs (9)
CMF-25141FLT3down-regulatesLHX3repressesR-2002244Drugs (19)
CMF-25142FLT3down-regulatesLHX3repressesR-2016244Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25144FLT3down-regulatesLHX3repressesR-2005244Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB

CMF-25151FLT3up-regulatesSP1repressesR-137082Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-25152FLT3up-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-25153FLT3up-regulatesRFX2activatesR-230061Drugs (16)
CMF-25162FLT3up-regulatesTCF4activatesR-1622172Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25163FLT3up-regulatesSOX2activatesR-2690161Drugs (19)
CMF-41930FLT3down-regulateshsa-mir-488repressesR-3143192Drugs (9)
CMF-41931FLT3down-regulateshsa-mir-488repressesR-2016192Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-41932FLT3up-regulateshsa-mir-195repressesR-59711Drugs (65)
CMF-41933FLT3down-regulateshsa-mir-490repressesR-3475351Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-41934FLT3down-regulateshsa-mir-203repressesR-3143131Drugs (9)