Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ADAMTS20_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04724 | ADAMTS20 | up-regulates | NR2E1 | activates | R-2391 | 9 | 5 | Drugs (1) |
| CMF-04729 | ADAMTS20 | down-regulates | VAX2 | represses | R-1271 | 7 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BKT140, BALIXAFORTIDE, MAVORIXAFOR, ULOCUPLUMAB, BURIXAFOR, PLERIXAFOR, MSX-122 |
| CMF-04731 | ADAMTS20 | down-regulates | SOX12 | activates | R-1113 | 18 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04732 | ADAMTS20 | up-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04734 | ADAMTS20 | up-regulates | MAF | activates | R-185 | 19 | 3 | Drugs (1) |
| CMF-04735 | ADAMTS20 | up-regulates | MAF | activates | R-189 | 19 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04741 | ADAMTS20 | down-regulates | SOX1 | represses | R-1831 | 20 | 4 | Drugs (2) |
| CMF-04743 | ADAMTS20 | down-regulates | POU4F1 | represses | R-2758 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04744 | ADAMTS20 | down-regulates | POU4F1 | represses | R-2763 | 11 | 3 | Drugs (1) |
| CMF-04745 | ADAMTS20 | down-regulates | POU4F1 | activates | R-2764 | 11 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04746 | ADAMTS20 | down-regulates | FEV | represses | R-3031 | 5 | 1 | Drugs (2) |
| CMF-04749 | ADAMTS20 | up-regulates | BCL6 | activates | R-627 | 23 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)RIMEGEPANT SULFATE, TELCAGEPANT, ATOGEPANT, UBROGEPANT, ERENUMAB, 2X-121, RIMEGEPANT, BI-44370, MK3207, DAVALINTIDE, OLCEGEPANT |
| CMF-04750 | ADAMTS20 | up-regulates | JUN | activates | R-228 | 25 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)CELGOSIVIR, DUVOGLUSTAT, DUVOGLUSTAT HYDROCHLORIDE, AT-13148, MIGLITOL, VOGLIBOSE |
| CMF-04751 | ADAMTS20 | up-regulates | JUN | activates | R-214 | 25 | 5 | Drugs (3) |
| CMF-04752 | ADAMTS20 | up-regulates | JUN | activates | R-225 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04753 | ADAMTS20 | up-regulates | JUN | activates | R-224 | 25 | 5 | Drugs (1) |
| CMF-04755 | ADAMTS20 | up-regulates | MEOX2 | activates | R-2203 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04756 | ADAMTS20 | down-regulates | LHX3 | represses | R-2002 | 24 | 4 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-04759 | ADAMTS20 | down-regulates | LHX3 | represses | R-1996 | 24 | 4 | Drugs (2) |
| CMF-04760 | ADAMTS20 | up-regulates | STAT5A | activates | R-2945 | 21 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04761 | ADAMTS20 | up-regulates | STAT5A | activates | R-2955 | 21 | 4 | Drugs (1) |
| CMF-04765 | ADAMTS20 | up-regulates | ZIC1 | activates | R-3437 | 8 | 2 | Drugs (1) |
| CMF-04766 | ADAMTS20 | up-regulates | ZIC1 | activates | R-3436 | 8 | 2 | Drugs (1) |
| CMF-04767 | ADAMTS20 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04771 | ADAMTS20 | down-regulates | E2F1 | activates | R-530 | 18 | 4 | Drugs (1) |
| CMF-04776 | ADAMTS20 | down-regulates | LHX5 | represses | R-3056 | 11 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-04782 | ADAMTS20 | down-regulates | GFI1 | represses | R-1217 | 13 | 4 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-04783 | ADAMTS20 | down-regulates | PAX2 | represses | R-1185 | 4 | 1 | Drugs (1) |
| CMF-04789 | ADAMTS20 | down-regulates | NR0B1 | represses | R-2532 | 3 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-34718 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-2431 | 29 | 6 | Drugs (2) |
| CMF-34719 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-2798 | 29 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34720 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-2830 | 29 | 6 | Drugs (2) |
| CMF-34721 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-2864 | 29 | 6 | Drugs (2) |
| CMF-34722 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-3449 | 29 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-34723 | ADAMTS20 | down-regulates | hsa-mir-33 | represses | R-3604 | 29 | 6 | Drugs (1) |