Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
YWHAZ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396). Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396). Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396). Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7534 | ENSG00000164924 | YWHAZ | P63104 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1304 | Pr-131 | 1 | 1 | 22 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2078 | Pr-131 | 1 | 1 | 20 |
| R-235 | Pr-131 | 1 | 1 | 7 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2609 | Pr-131 | 1 | 1 | 17 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2671 | Pr-131 | 1 | 1 | 7 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2995 | Pr-131 | 1 | 1 | 4 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3031 | Pr-131 | 1 | 1 | 36 |
| R-3072 | Pr-131 | 1 | 1 | 41 |
| R-3231 | Pr-131 | 1 | 1 | 53 |
| R-3449 | Pr-131 | 1 | 1 | 60 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-3481 | Pr-12 | 1 | 1 | 45 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-995 | Pr-131 | 1 | 1 | 19 |