Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
WWTR1 - WW domain containing transcription regulator 1
Function
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213, PubMed:18227151). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18227151). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (PubMed:19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed:18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed:18227151, PubMed:18568018).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 25937 | ENSG00000018408 | WWTR1 | Q9GZV5 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1304 | Pr-131 | 1 | 1 | 22 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2372 | Pr-131 | 1 | 1 | 7 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2454 | Pr-13 | 1 | 1 | 6 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2671 | Pr-131 | 1 | 1 | 7 |
| R-2783 | Pr-131 | 1 | 1 | 28 |
| R-2798 | Pr-17 | 1 | 1 | 50 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2940 | Pr-12 | 1 | 1 | 75 |
| R-2995 | Pr-131 | 1 | 1 | 4 |
| R-3008 | Pr-131 | 1 | 1 | 14 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3031 | Pr-131 | 1 | 1 | 36 |
| R-3072 | Pr-131 | 1 | 1 | 41 |
| R-3231 | Pr-131 | 1 | 1 | 53 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |