Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
VEGFA - vascular endothelial growth factor A
Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7422 | ENSG00000112715 | VEGFA | P15692 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1003 | Pr-169 | 1 | 1 | 9 |
| R-1018 | Pr-39 | 1 | 1 | 5 |
| R-1129 | Pr-39 | 1 | 1 | 15 |
| R-1166 | Pr-39 | 1 | 1 | 12 |
| R-121 | Pr-39 | 1 | 1 | 9 |
| R-1217 | Pr-169 | 1 | 1 | 6 |
| R-1285 | Pr-177 | 1 | 1 | 5 |
| R-1490 | Pr-39 | 1 | 1 | 13 |
| R-1571 | Pr-39 | 1 | 1 | 14 |
| R-1597 | Pr-39 | 1 | 1 | 9 |
| R-1790 | Pr-39 | 1 | 1 | 6 |
| R-1936 | Pr-6 | 1 | 1 | 14 |
| R-2002 | Pr-177 | 1 | 1 | 23 |
| R-2300 | Pr-39 | 1 | 1 | 13 |
| R-2690 | Pr-39 | 1 | 1 | 13 |
| R-2722 | Pr-39 | 1 | 1 | 4 |
| R-2845 | Pr-39 | 1 | 1 | 10 |
| R-2914 | Pr-39 | 1 | 1 | 14 |
| R-2929 | Pr-39 | 1 | 1 | 22 |
| R-2964 | Pr-39 | 1 | 1 | 26 |
| R-3106 | Pr-177 | 1 | 1 | 10 |
| R-320 | Pr-169 | 1 | 1 | 2 |
| R-3683 | Pr-39 | 1 | 1 | 20 |
| R-469 | Pr-169 | 1 | 1 | 17 |
| R-556 | Pr-39 | 1 | 1 | 6 |
| R-564 | Pr-169 | 1 | 1 | 4 |
| R-670 | Pr-177 | 1 | 1 | 17 |
| R-702 | Pr-39 | 1 | 1 | 4 |
| R-825 | Pr-39 | 1 | 1 | 9 |
| R-829 | Pr-169 | 1 | 1 | 3 |
| R-873 | Pr-39 | 1 | 1 | 6 |
| R-892 | Pr-177 | 1 | 1 | 2 |
| R-974 | Pr-39 | 1 | 1 | 5 |
| R-982 | Pr-169 | 1 | 1 | 2 |