Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
USP3 - ubiquitin specific peptidase 3
Function
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 9960 | ENSG00000140455 | USP3 | Q9Y6I4 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1105 | Pr-58 | 1 | 1 | 8 |
| R-1167 | Pr-58 | 1 | 1 | 6 |
| R-1227 | Pr-58 | 1 | 1 | 4 |
| R-1270 | Pr-148 | 1 | 1 | 2 |
| R-1528 | Pr-58 | 1 | 1 | 3 |
| R-1600 | Pr-58 | 1 | 1 | 7 |
| R-1632 | Pr-58 | 1 | 1 | 9 |
| R-1682 | Pr-58 | 1 | 1 | 17 |
| R-1792 | Pr-58 | 1 | 1 | 1 |
| R-2253 | Pr-58 | 1 | 1 | 7 |
| R-2757 | Pr-58 | 1 | 1 | 19 |
| R-2891 | Pr-58 | 1 | 1 | 5 |
| R-303 | Pr-58 | 1 | 1 | 3 |
| R-3289 | Pr-58 | 1 | 1 | 5 |
| R-3339 | Pr-58 | 1 | 1 | 5 |
| R-3462 | Pr-58 | 1 | 1 | 12 |
| R-723 | Pr-58 | 1 | 1 | 14 |