Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TCIRG1 - T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation (PubMed:10329006).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10312 | ENSG00000110719 | TCIRG1 | Q13488 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-114 | Pr-0 | 1 | 1 | 12 |
| R-138 | Pr-0 | 1 | 1 | 7 |
| R-1517 | Pr-0 | 1 | 1 | 10 |
| R-153 | Pr-15 | 1 | 1 | 16 |
| R-209 | Pr-0 | 1 | 1 | 6 |
| R-2113 | Pr-0 | 1 | 1 | 5 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2449 | Pr-15 | 1 | 1 | 10 |
| R-2498 | Pr-0 | 1 | 1 | 17 |
| R-2507 | Pr-15 | 1 | 1 | 14 |
| R-2509 | Pr-0 | 1 | 1 | 9 |
| R-2539 | Pr-0 | 1 | 1 | 2 |
| R-276 | Pr-0 | 1 | 1 | 13 |
| R-294 | Pr-0 | 1 | 1 | 19 |
| R-3094 | Pr-137 | 1 | 1 | 9 |
| R-3124 | Pr-137 | 1 | 1 | 4 |
| R-3127 | Pr-0 | 1 | 1 | 7 |
| R-3133 | Pr-0 | 1 | 1 | 8 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-398 | Pr-133 | 1 | 1 | 4 |
| R-418 | Pr-0 | 1 | 1 | 12 |
| R-648 | Pr-0 | 1 | 1 | 7 |
| R-991 | Pr-0 | 1 | 1 | 7 |