Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SLCO3A1 - solute carrier organic anion transporter family member 3A1
Function
Mediates the Na(+)-independent transport of organic anions such as prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin (PubMed:16971491, PubMed:19129463). Also displays a low transport activity of estrone 3-sulfate (PubMed:10873595, PubMed:16971491, PubMed:19129463). Shows a pH-sensitive substrate specificity towards T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 28232 | ENSG00000176463 | SLCO3A1 | Q9UIG8 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|