Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SEL1L - SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6400 | ENSG00000071537 | SEL1L | Q9UBV2 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-1755 | Pr-19 | 1 | 1 | 3 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2078 | Pr-131 | 1 | 1 | 20 |
| R-2104 | Pr-131 | 1 | 1 | 23 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-235 | Pr-131 | 1 | 1 | 7 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2940 | Pr-12 | 1 | 1 | 75 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-3481 | Pr-12 | 1 | 1 | 45 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |