Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
RALB - RAS like proto-oncogene B
Function
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5899 | ENSG00000144118 | RALB | P11234 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1037 | Pr-131 | 1 | 1 | 7 |
| R-113 | Pr-138 | 1 | 1 | 10 |
| R-1304 | Pr-131 | 1 | 1 | 22 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-1466 | Pr-144 | 1 | 1 | 4 |
| R-1521 | Pr-131 | 1 | 1 | 20 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1699 | Pr-131 | 1 | 1 | 18 |
| R-177 | Pr-131 | 1 | 1 | 55 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1903 | Pr-131 | 1 | 1 | 9 |
| R-2033 | Pr-144 | 1 | 1 | 7 |
| R-2104 | Pr-131 | 1 | 1 | 23 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-2193 | Pr-144 | 1 | 1 | 10 |
| R-2426 | Pr-137 | 1 | 1 | 92 |
| R-2451 | Pr-131 | 1 | 1 | 68 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2783 | Pr-131 | 1 | 1 | 28 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2940 | Pr-12 | 1 | 1 | 75 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3072 | Pr-131 | 1 | 1 | 41 |
| R-3231 | Pr-131 | 1 | 1 | 53 |
| R-3459 | Pr-131 | 1 | 1 | 56 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |
| R-995 | Pr-131 | 1 | 1 | 19 |