Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PTPN1 - protein tyrosine phosphatase non-receptor type 1
Function
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5770 | ENSG00000196396 | PTPN1 | P18031 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1038 | Pr-3 | 1 | 1 | 2 |
| R-1085 | Pr-3 | 1 | 1 | 3 |
| R-1161 | Pr-3 | 1 | 1 | 3 |
| R-1284 | Pr-5 | 1 | 1 | 7 |
| R-1486 | Pr-3 | 1 | 1 | 6 |
| R-162 | Pr-3 | 1 | 1 | 8 |
| R-1646 | Pr-3 | 1 | 1 | 4 |
| R-1831 | Pr-3 | 1 | 1 | 10 |
| R-1905 | Pr-3 | 1 | 1 | 12 |
| R-1907 | Pr-5 | 1 | 1 | 13 |
| R-1984 | Pr-21 | 1 | 1 | 8 |
| R-1995 | Pr-3 | 1 | 1 | 9 |
| R-1999 | Pr-5 | 1 | 1 | 7 |
| R-2080 | Pr-3 | 1 | 1 | 8 |
| R-2127 | Pr-5 | 1 | 1 | 2 |
| R-213 | Pr-5 | 1 | 1 | 8 |
| R-2210 | Pr-3 | 1 | 1 | 2 |
| R-2323 | Pr-5 | 1 | 1 | 6 |
| R-2497 | Pr-3 | 1 | 1 | 7 |
| R-2623 | Pr-5 | 1 | 1 | 8 |
| R-2688 | Pr-5 | 1 | 1 | 16 |
| R-2707 | Pr-3 | 1 | 1 | 10 |
| R-2758 | Pr-3 | 1 | 1 | 16 |
| R-2887 | Pr-3 | 1 | 1 | 14 |
| R-2961 | Pr-5 | 1 | 1 | 16 |
| R-2965 | Pr-3 | 1 | 1 | 13 |
| R-3054 | Pr-3 | 1 | 1 | 6 |
| R-3135 | Pr-3 | 1 | 1 | 15 |
| R-3548 | Pr-5 | 1 | 1 | 6 |
| R-3549 | Pr-3 | 1 | 1 | 8 |
| R-3580 | Pr-3 | 1 | 1 | 12 |
| R-376 | Pr-5 | 1 | 1 | 15 |
| R-378 | Pr-3 | 1 | 1 | 85 |
| R-510 | Pr-3 | 1 | 1 | 4 |
| R-578 | Pr-3 | 1 | 1 | 6 |
| R-700 | Pr-3 | 1 | 1 | 2 |