Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PFN1 - profilin 1
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 5216 | ENSG00000108518 | PFN1 | P07737 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1068 | Pr-0 | 1 | 1 | 4 |
| R-1100 | Pr-0 | 1 | 1 | 8 |
| R-1300 | Pr-0 | 1 | 1 | 25 |
| R-1356 | Pr-0 | 1 | 1 | 4 |
| R-138 | Pr-0 | 1 | 1 | 7 |
| R-1550 | Pr-0 | 1 | 1 | 3 |
| R-175 | Pr-0 | 1 | 1 | 11 |
| R-176 | Pr-143 | 1 | 1 | 4 |
| R-1813 | Pr-0 | 1 | 1 | 2 |
| R-1904 | Pr-0 | 1 | 1 | 9 |
| R-1925 | Pr-0 | 1 | 1 | 1 |
| R-1982 | Pr-137 | 1 | 1 | 14 |
| R-209 | Pr-0 | 1 | 1 | 6 |
| R-2100 | Pr-0 | 1 | 1 | 12 |
| R-2113 | Pr-0 | 1 | 1 | 5 |
| R-2317 | Pr-0 | 1 | 1 | 10 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2498 | Pr-0 | 1 | 1 | 17 |
| R-258 | Pr-0 | 1 | 1 | 9 |
| R-2589 | Pr-0 | 1 | 1 | 4 |
| R-2687 | Pr-0 | 1 | 1 | 14 |
| R-294 | Pr-0 | 1 | 1 | 19 |
| R-297 | Pr-143 | 1 | 1 | 21 |
| R-3039 | Pr-0 | 1 | 1 | 6 |
| R-3096 | Pr-133 | 1 | 1 | 9 |
| R-3149 | Pr-0 | 1 | 1 | 7 |
| R-357 | Pr-0 | 1 | 1 | 8 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-418 | Pr-0 | 1 | 1 | 12 |
| R-648 | Pr-0 | 1 | 1 | 7 |
| R-991 | Pr-0 | 1 | 1 | 7 |