Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
PELO - pelota mRNA surveillance and ribosome rescue factor
Function
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:29861391). In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 53918 | ENSG00000152684 | PELO | Q9BRX2 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1102 | Pr-5 | 1 | 1 | 7 |
| R-1284 | Pr-5 | 1 | 1 | 7 |
| R-1760 | Pr-5 | 1 | 1 | 5 |
| R-178 | Pr-5 | 1 | 1 | 6 |
| R-1907 | Pr-5 | 1 | 1 | 13 |
| R-1984 | Pr-21 | 1 | 1 | 8 |
| R-1999 | Pr-5 | 1 | 1 | 7 |
| R-213 | Pr-5 | 1 | 1 | 8 |
| R-2281 | Pr-5 | 1 | 1 | 14 |
| R-2323 | Pr-5 | 1 | 1 | 6 |
| R-2355 | Pr-5 | 1 | 1 | 4 |
| R-2590 | Pr-5 | 1 | 1 | 6 |
| R-2623 | Pr-5 | 1 | 1 | 8 |
| R-2688 | Pr-5 | 1 | 1 | 16 |
| R-2961 | Pr-5 | 1 | 1 | 16 |
| R-2987 | Pr-5 | 1 | 1 | 5 |
| R-3105 | Pr-5 | 1 | 1 | 7 |
| R-3162 | Pr-5 | 1 | 1 | 9 |
| R-3548 | Pr-5 | 1 | 1 | 6 |
| R-3692 | Pr-133 | 1 | 1 | 10 |
| R-376 | Pr-5 | 1 | 1 | 15 |
| R-466 | Pr-5 | 1 | 1 | 12 |