Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
MCL1 - MCL1 apoptosis regulator, BCL2 family member
Function
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4170 | ENSG00000143384 | MCL1 | Q07820 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1289 | Pr-15 | 1 | 1 | 4 |
| R-146 | Pr-15 | 1 | 1 | 16 |
| R-165 | Pr-15 | 1 | 1 | 10 |
| R-1728 | Pr-15 | 1 | 1 | 9 |
| R-180 | Pr-15 | 1 | 1 | 6 |
| R-1970 | Pr-15 | 1 | 1 | 10 |
| R-2039 | Pr-15 | 1 | 1 | 2 |
| R-2101 | Pr-15 | 1 | 1 | 10 |
| R-222 | Pr-15 | 1 | 1 | 10 |
| R-2805 | Pr-15 | 1 | 1 | 4 |
| R-2949 | Pr-15 | 1 | 1 | 15 |
| R-3137 | Pr-15 | 1 | 1 | 16 |
| R-3293 | Pr-15 | 1 | 1 | 6 |
| R-3582 | Pr-15 | 1 | 1 | 12 |
| R-367 | Pr-15 | 1 | 1 | 6 |
| R-3776 | Pr-15 | 1 | 1 | 3 |
| R-405 | Pr-15 | 1 | 1 | 2 |