Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
EDEM3 - ER degradation enhancing alpha-mannosidase like protein 3
Function
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655). May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952). May have alpha 1,2-mannosidase activity (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 80267 | ENSG00000116406 | EDEM3 | Q9BZQ6 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1067 | Pr-131 | 1 | 1 | 49 |
| R-1448 | Pr-131 | 1 | 1 | 1 |
| R-1463 | Pr-131 | 1 | 1 | 6 |
| R-160 | Pr-131 | 1 | 1 | 10 |
| R-1645 | Pr-131 | 1 | 1 | 57 |
| R-1853 | Pr-131 | 1 | 1 | 35 |
| R-1945 | Pr-131 | 1 | 1 | 9 |
| R-2104 | Pr-131 | 1 | 1 | 23 |
| R-2145 | Pr-131 | 1 | 1 | 21 |
| R-2372 | Pr-131 | 1 | 1 | 7 |
| R-2622 | Pr-131 | 1 | 1 | 35 |
| R-2841 | Pr-131 | 1 | 1 | 10 |
| R-2883 | Pr-131 | 1 | 1 | 29 |
| R-2940 | Pr-12 | 1 | 1 | 75 |
| R-2995 | Pr-131 | 1 | 1 | 4 |
| R-3013 | Pr-131 | 1 | 1 | 50 |
| R-3036 | Pr-131 | 1 | 1 | 3 |
| R-377 | Pr-131 | 1 | 1 | 22 |
| R-415 | Pr-131 | 1 | 1 | 39 |
| R-576 | Pr-131 | 1 | 1 | 41 |
| R-626 | Pr-131 | 1 | 1 | 52 |
| R-679 | Pr-131 | 1 | 1 | 63 |
| R-738 | Pr-131 | 1 | 1 | 45 |
| R-970 | Pr-131 | 1 | 1 | 56 |