Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CTSC - cathepsin C
Function
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1075 | ENSG00000109861 | CTSC | P53634 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-157 | Pr-28 | 1 | 1 | 19 |
| R-1592 | Pr-4 | 1 | 1 | 87 |
| R-1829 | Pr-4 | 1 | 1 | 83 |
| R-1895 | Pr-28 | 1 | 1 | 7 |
| R-2123 | Pr-4 | 1 | 1 | 85 |
| R-2161 | Pr-4 | 1 | 1 | 71 |
| R-2331 | Pr-28 | 1 | 1 | 6 |
| R-245 | Pr-28 | 1 | 1 | 30 |
| R-2456 | Pr-4 | 1 | 1 | 3 |
| R-2477 | Pr-4 | 1 | 1 | 77 |
| R-252 | Pr-4 | 1 | 1 | 15 |
| R-259 | Pr-4 | 1 | 1 | 17 |
| R-2601 | Pr-28 | 1 | 1 | 13 |
| R-2765 | Pr-28 | 1 | 1 | 15 |
| R-2767 | Pr-4 | 1 | 1 | 70 |
| R-2781 | Pr-28 | 1 | 1 | 10 |
| R-2885 | Pr-4 | 1 | 1 | 81 |
| R-2943 | Pr-4 | 1 | 1 | 14 |
| R-298 | Pr-4 | 1 | 1 | 11 |
| R-3029 | Pr-28 | 1 | 1 | 20 |
| R-3126 | Pr-4 | 1 | 1 | 11 |
| R-3131 | Pr-28 | 1 | 1 | 11 |
| R-3134 | Pr-4 | 1 | 1 | 97 |
| R-3345 | Pr-4 | 1 | 1 | 2 |
| R-3377 | Pr-4 | 1 | 1 | 7 |
| R-3571 | Pr-28 | 1 | 1 | 9 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-419 | Pr-4 | 1 | 1 | 90 |
| R-449 | Pr-4 | 1 | 1 | 10 |
| R-737 | Pr-4 | 1 | 1 | 72 |