Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
CD63 - CD63 molecule
Function
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 967 | ENSG00000135404 | CD63 | P08962 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1248 | Pr-85 | 1 | 1 | 19 |
| R-1408 | Pr-85 | 1 | 1 | 7 |
| R-1476 | Pr-82 | 1 | 1 | 6 |
| R-1784 | Pr-43 | 1 | 1 | 11 |
| R-1802 | Pr-85 | 1 | 1 | 14 |
| R-1812 | Pr-43 | 1 | 1 | 5 |
| R-184 | Pr-82 | 1 | 1 | 18 |
| R-1848 | Pr-43 | 1 | 1 | 8 |
| R-1900 | Pr-43 | 1 | 1 | 7 |
| R-1924 | Pr-43 | 1 | 1 | 3 |
| R-1931 | Pr-82 | 1 | 1 | 7 |
| R-1942 | Pr-43 | 1 | 1 | 12 |
| R-1963 | Pr-43 | 1 | 1 | 8 |
| R-2020 | Pr-20 | 1 | 1 | 33 |
| R-2031 | Pr-43 | 1 | 1 | 15 |
| R-647 | Pr-43 | 1 | 1 | 15 |
| R-666 | Pr-43 | 1 | 1 | 20 |
| R-821 | Pr-20 | 1 | 1 | 10 |